Background: Monoclonal antibodies have confirmed their merit as biotherapeutics across a wide spectrum of diseases, including cancer, heart disease, infection, and immune disorders. Materials and Methods: The dynamics of 89Zr-labelled monoclonal antibodies (MAb) after injection into the human body are modelled. This modified biokinetic model can be used for dose assessment not only for 89Zr-lab...

in recent years, several radiopharmaceuticals have been developed for imaging regional cerebral blood flow (rcbf) such as 75se labelled pipse and mose, ²º¹ti labelled ddc and 99mtc labelled hmpao. hmpao with two asymmetric carbon atoms (at the 3 and 9 positions), produces d,1 and meso isomers, only one of which is retained in the brain. rapid intracellular conversion of 99mtc-d,1-hmpao to hydro...

A simple technique is described for producing high-quality functional images of regional ventilation during physiological tidal breathing of the inert gas 81mKr. These images are quickly obtained on a gamma-camera without the need of computerized systems for data acquisition and display and are directly comparable with those of perfusion obtained with 99mTc-labelled macroaggregates. The short t...

myocardial ischemia (mi) resulting in infarction is an important cause of mortality and morbidity worldwide. acute ischaemia rapidly impairs myocardial contractile function. myocardial dysfunction persisting for several hours after transient non-lethal ischaemia, eventually resulting in full functional recovery is termed as myocardial stunning. hibernation is now thought to be the consequence o...

To study the distribution and localization of oil-soluble arteether in experimental mice, we injected C14-labelled arteether (20 microCi/kg body weight) intramuscularly and measured radioactivity in the blood, kidney, and liver. The labelled arteether distributed and localized more to the kidney (819,180.4 +/- 34,134 dpm/cm3) than the liver (288,628.9 +/- 54,954 dpm/cm3) 4 hours post-injection....

We add labels to first-order clauses to simultaneously apply superpositions to several proof obligations inside one clause set. From a theoretical perspective, the approach unifies a variety of deduction modes. These include different strategies such as set of support, as well as explicit case analysis, e.g., splitting. From a practical perspective, labelled clauses offer advantages in the case...