BACKGROUND Sclerocornea, a congenital corneal pathology characterized by bilateral scleralization of the cornea, which can be found in few cases with posterior fossa malformationshemangiomas-arterial anomalies-cardiac defects-eye abnormalities-sternal cleft and supraumbilical raphe (PHACES) syndrome. Presence of vascularization in peripheral cornea and smaller diameter of recipient cornea corre...

eyf served as a control. Intraperitoneal [Ii ]-thyeidine was injected. Three eyes were studied histologically and autoradiographically at 1 hr, 3 hr. 6 hr. 9 hr, 12 hr, 24 hr, 2 d, 3 d, 9 d, 12 d, 15 d, 18 d and 21 d. The epithelial cells were scanned from limbus to limbus. Analysis of variance and linear regression (SPSS package) were used for statistical evaluation. Results: The cells prolife...

The collagen microstructure of the peripheral cornea is important in stabilizing corneal curvature and refractive status. However, the manner in which the predominantly orthogonal collagen fibrils of the central cornea integrate with the circumferential limbal collagen is unknown. We used microfocus wide-angle x-ray scattering to quantify the relative proportion and orientation of collagen fibr...

eyf served as a control. Intraperitoneal [Ii ]-thyeidine was injected. Three eyes were studied histologically and autoradiographically at 1 hr, 3 hr. 6 hr. 9 hr, 12 hr, 24 hr, 2 d, 3 d, 9 d, 12 d, 15 d, 18 d and 21 d. The epithelial cells were scanned from limbus to limbus. Analysis of variance and linear regression (SPSS package) were used for statistical evaluation. Results: The cells prolife...

eyf served as a control. Intraperitoneal [Ii ]-thyeidine was injected. Three eyes were studied histologically and autoradiographically at 1 hr, 3 hr. 6 hr. 9 hr, 12 hr, 24 hr, 2 d, 3 d, 9 d, 12 d, 15 d, 18 d and 21 d. The epithelial cells were scanned from limbus to limbus. Analysis of variance and linear regression (SPSS package) were used for statistical evaluation. Results: The cells prolife...

BACKGROUND/AIMS During the healing of corneal epithelial wounds with limbal involvement, conjunctival epithelium often migrates across the denuded limbus to cover the corneal surface. It is believed that, over a period of time, conjunctival epithelium covering the cornea assumes characteristics of corneal epithelium by a process referred to as conjunctival transdifferentiation. The purpose of t...

The ocular surface consists of two distinct types of epithelial cells; conjunctival and corneal. Although anatomically continuous, these epithelia comprise two distinct cell populations. Corneal stem cells are located at the limbus. The microenvironment of the limbus is important in maintaining "stemness" of the stem cells and also acts as a barrier to conjunctival epithelial cells preventing t...

The aim of this study was to detect a spectrum of cytokeratins (CK) present in the adult human cornea, limbus and perilimbal conjunctiva. Cryosections from seven corneo-scleral discs were fixed, and indirect immunofluorescent staining was performed using antibodies directed against CK1-CK10 and CK13-CK20. The percentage of positive cells was calculated in the epithelium of the cornea, limbus an...

The limbus is a narrow band of tissue that encircles the cornea, the transparent 'window' into the eye. The outermost layer of the cornea is the epithelium, which is necessary for clear vision. The limbus acts as a 'reservoir' for limbal stem cells which maintain and regenerate the corneal epithelium. It also functions as a barrier to the conjunctiva and its blood vessels. Limbal stem cell defi...

PURPOSE To determine how mechanical interaction among iris, cornea, limbus, sclera, and IOP contribute to angle opening during indentation of the cornea or sclera. METHODS A finite-element model of the globe was developed. The model consisted of three elastic isotropic segments--iris, cornea, and sclera--and a two-component anisotropic segment representing the limbus. The model was tested aga...