The goals of post-transplant management are to manage and treat postoperative complications, and develop a balanced long-term immunotherapy regimen that minimizes infection and side effects but controls rejection. While modern immunosuppressant regimes have reduced rates of graft loss due to rejection, they impart major risks for infection, growth failure, metabolic complications, and malignanc...

background liver transplantation is a life-saving intervention for many patients with end-stage liver disease. in the past, evaluation of successful liver transplantation was based on patients’ survival rate. however, in recent years this evaluation has been based on patients’ quality of life. various instruments have been developed to evaluate patients’ quality of life. nonetheless, scholars s...

Background: Interleukin-17 (IL-17), as a potent proinflammatory cytokine, has a critical role in post liver transplant outcomes. However, there is not much information about the effects of IL-17 cytokine on acute liver rejection. Objective: To evaluate the role of IL-17 in post-liver transplant acute rejection. Methods: Ninety seven adult liver transplant patients who enrolled in this cross sec...

Background: Dendritic cells (DCs) are potent antigen presenting cells for triggering of the immune reaction post transplantation. These cells are centrally involved in the initiation of T cell-dependent immune responses. Objective: To compare the level of DC maturation and function in liver transplant recipients with healthy controls. Methods: In this study, twelve peripheral blood samples we...

introduction: cytomegalovirus (cytome-galovirus: cmv) infection is a common cause of morbidity and mortality in patients who are the candidate for liver transplant. serological monitoring of individuals rece-iving and giving the liver transplant is necessary for prevention, early diagnosis and treatment strategies and reducing the prevalence of infection. the aim of this study was to assess the...

background: interleukin-17 (il-17), as a potent proinflammatory cytokine, has a critical role in post liver transplant outcomes. however, there is not much information about the effects of il-17 cytokine on acute liver rejection. objective: to evaluate the role of il-17 in post-liver transplant acute rejection. methods: ninety seven adult liver transplant patients who enrolled in this cross sec...

introduction since directly acting antivirals (daas) for treatment of hepatitis c virus (hcv) were introduced, conflicting data emerged about the risk of hepatocellular carcinoma (hcc) after interferon (ifn)-free treatments. we present a case of recurrent, extra-hepatic hcc in a liver-transplanted patient soon after successful treatment with daas, along with a short review of literature. conclu...

background hepatitis c virus (hcv) infection is one the major health concern among the infected transplant patients. considering several complications of the disease in them, pre and post-transplantation studies should be performed for monitoring of the infection, as well as, developing new treatment protocols. objectives the current study was conducted to determine the hepatitis c virus rna le...