background and objectives: helicobacter pylori is the causative agent of peptic ulcer disease and a co-factor in development of gastric malignancies. lps are among toxic substances produced by h. pylori exhibiting low endotoxic activity compared to typical bacterial lps. the aim of this study was to investigate bioactivity of lps produced by different serotypes of helicobacter pylori compared t...

In the present study the protective effect of Nigella sativa (N. sativa)on synaptic plasticity impairment induced by lipopolysaccharide (LPS) in rats was investigated. Fifty-eight rats were grouped and treated as follows: 1) control (saline), 2) LPS, 3) LPS-N. sativa,and 4) N. sativa. In a Morris water maze test, the escape latency and traveled path to find t...

background: camellia sinensis and zataria multiflora as the potent antioxidants and anti-inflammations are crucial in the management of wound therapy. lipopolysaccharide (lps) was used for the proliferative potential on fibroblast cells and induction of inflammatory mediators. objective: we examined the effects of lps and herbal extracts combination in order to identify their mechanisms of acti...

background: dendritic cells (dcs) are professional antigen presenting cells that have an important role in the initiation of immune response. the use of maturation factors in dendritic cell differentiation provides a promising approach in immunotherapy. objective: in this study, we compared tumor necrosis factor-α, polyribocytidylic acid, lipopolysacharide and cpg oligonucleotides in inducing d...

Background: Activation of inflammatory cells can cause more chemicals induced-hepatotoxicity. Aflatoxin B1 (AFB1) is a fungal toxin that induces acute hepatotoxicity in humans and animals. This study was conducted to examine the effect of co-exposure LPS and various aflatoxin B1 doses on the damage hepatic parameters in isolated perfused rat liver. Methods: Thirty-two male wistar rats (250-3...

conclusions purified lps can be considered as a safe adjuvant and can be used as a component in prophylactic and therapeutic vaccines targeting infectious disease, cancer and allergies. results biochemical analysis data and sds-page profile showed that the chemical nature of s19 lps is different from rb51 lps. both s and r-lps induce an immune response. t-cell immune response induced by both s ...

background: activation of inflammatory cells can cause more chemicals induced-hepatotoxicity. aflatoxin b1 (afb1) is a fungal toxin that induces acute hepatotoxicity in humans and animals. this study was conducted to examine the effect of co-exposure lps and various aflatoxin b1 doses on the damage hepatic parameters in isolated perfused rat liver. methods: thirty-two male wistar rats (250-300g...

conclusions vaccine based on the conjugation of p. aeruginosa pao-1 lps with dt increased anti-lps antibodies and had a significant potential to protect against pseudomonas infections. background treatment of pseudomonas aeruginosa pao-1 infections through immunological means has been proved to be efficient and protective. objectives the purpose of this study was to produce a conjugate vaccine ...

Neuro-immune mediators play an important role in the development of sickness behaviors. In the present study, the effect of captopril on sickness behaviors caused by lipopolysaccharide (LPS) was studied in the rats. The animals were randomized into the following groups: control, sham, 10 mg kg-1 captopril - LPS (Capto 10-LPS), 50 mg kg-1 captopril - LPS (Capto 50-LPS), and...

Objective: Neuroimmune factors contribute on the pathogenesis of sickness behaviors. Nigella sativa (NS) has anti-inflammatory, anti-anxiety and anti-depressive effects. In the present study, the effect of NS hydro-alcoholic extract on sickness behavior induced by lipopolysaccharide (LPS) was investigated. Materials and Methods: The rats were divided into five groups (n=10 in each): (1) control...