the present study was carried out to investigate cytotoxic activity of flower, leaf, stem and root extracts of five artemisia species against breast cancer cell line (mcf7) and human embryonic kidney normal cell line (hek293). the studied artemisia species were a. absinthium , a. vulgaris , a. incana , a. fragrans and a. spicigera . the cytotoxic activity was measured by mtt assay at different ...

Introduction: Hydroxyapatite nanoparticles inhibit the growth of various cancer cells. The inhibitory effect of these nanoparticles on breast cancer cells of mcf7 has also been reported. However, no studies have been done on the effect of the hydroxyapatite nanoparticles on the radiation sensitivities of the MCF7 cell Line. Our goal in this study is to investigate the effect of...

We examined the role of multidrug resistance protein (MRP) 1 (ABCC1) in the emergence of mitoxantrone (MX) cross-resistance in a MCF7 breast cancer cell line selected for resistance to etoposide. The resistant cell line, MCF7/VP, expresses high levels of MRP1, whereas the parental cell line, MCF7/WT, does not. MCF7/VP cells are 6-10-fold cross-resistant to MX when compared with MCF7/WT cells. D...

ATP-binding cassette (ABC) membrane proteins comprise a superfamily of transporters with a wide variety of substrates. Humans have 49 members in this superfamily. Several human ABC transporters, such as ABCB1 and ABCC1, have been attributed to cause multidrug resistance (MDR) in cancer treatment when over-expressed. In the past, an MDR cancer cell line MCF7/AdVp3000 has been selected, and overe...

In continuation of previous research, the anticancer screening formulation herbal syrup Vinca extract was performed. The performed as per reported literature method. cancer on two Human cell lines. These lines were Lung Cancer line A549 and Breast Cell MCF7. found to be devoid properties.

Objective(s): The purpose of this study was to evaluate variations in yields, volatile composition and biological activities of essential oils (EOs) obtained from the aerial parts of Zhumeria majdae collected from five localities of the south of Iran. Materials and Methods: The EOs were analyzed using gas chromatography and gas chromatography-mass spectrometry techniques. The antioxidant activi...

Estrogen receptor alpha positive (ER+) of breast cancer could develop resistance to antiestrogens including Tamoxifen. Our previous study showed that the E3 ubiquitin ligase HRD1 played an important role in anti-breast cancer. However, its role in chemotherapy resistance hasn't been reported. In this study, we found that HRD1 expression was downregulated in Tamoxifen-resistant breast cancer cel...

Tumor cell cycle arrest at the cell cycle G2/M boundary after ionizing radiation involves inhibition of the Polo-like kinase 1 (Plk1). We recently found that the mechanism comprised repression of its gene, PLK, mediated by the tumor-suppressor protein BRCA1. In the present study we examined the regulatory responses on PLK and cell cycle phases in breast carcinoma cell lines exposed to various m...