this study was conducted to compare the bio-efficacy of herbal methionine (h-met) relative to dl-methionine (dl-met) on 160 “ross 308” broiler chickens. dl-met and h-met were added to the basal diet in eight experimental treatments with three and four concentrations respectively in starter, grower and finisher period. blood parameters which were measured at 24 and 42 days of age consisted of: s...

A new study by Sennino and colleagues demonstrates that selective VEGF inhibition via the use of an anti-VEGF antibody is sufficient to increase invasion and metastasis in a c-Met-dependent manner. Anti-VEGF therapy induced tumor hypoxia, hypoxia-inducible factor 1α, and c-Met activation in the RIP-Tag2 model of neuroendocrine pancreatic cancer. Selective c-Met inhibition was sufficient to bloc...

Density functional theory methods(DFT) and natural bond orbital (NBO) analysis were used to investigate the effects of isomerism and side chain mutation at a microscopic level on the stability, binding energy and NMR/NQR tensors of structural isomers, L- methionylasparagine (Met-Asn) and L- asparagylmethionine (Asn-Met) in the gas phase. The results represented that the isomerism and side chain...

BACKGROUND Activation of beta-catenin is a hallmark of hepatoblastoma (HB) and appears to play a crucial role in its pathogenesis. While aberrant accumulation of the beta-catenin is a common event in HB, mutations or deletions in CTNNB1 (beta-catenin gene) do not always account for the high frequency of protein expression. In this study we have investigated alternative activation of beta-cateni...

The Maritime Education and Training (MET) instructors play an important role in maritime safety. They educate, train prepare new existing seafarers for efficient safe job performance ultimately shape the safety sustainability of shipping operations. To assist performing their tasks appropriately, International Organization (IMO) has developed various IMO model courses. paper addresses factors t...