Microbial b-lactone natural products An annotated selection of World Wide Web sites relevant to the topics in microbial biotechnology. Obafluorin is an antimicrobial b-lactone compound produced by the bacterium Pseudomonas fluorescens. In this study, the compound was synthesized, analysed chemically and tested for biological activity. The triedimycins are a class of spiro b-lactones. They are n...

This article revises the current state of microbial transformation use in natural products. It represents the results of the most recent reports. Due to the importance of this transformation, there is still a strong need to intensify the direction of microbial transformation of the natural product compounds, besides exploiting more microorganisms that might be the used biocatalysts in producing...

Small-molecule secondary metabolites isolated from microorganisms and plants provide the chemical scaffolds of a large fraction of today’s pharmaceuticals. Evolutionary forces shaped the molecular complexity of these natural products that contribute to the exquisite binding of these compounds to biological targets. Starting with the discovery of penicillin by Fleming, we have seen a rapid incre...