the adaptive response (ar) is a phenomenon by which cells exposure to sublethal doses of dna-damaging agents (non-mutagenic dose of chemical or radiation), known as conditioning treatment (ct), leads to increased resistance to a subsequent exposure to a higher dose of the same or other agents, known as challenge treatment (cr). the adaptive response (ar) induced by radiation in human lymphocyte...

Background: This study was conducted to investigate both the genotoxicity effects of M. officinalis aqueous extract on blood cells and the pathologic changes in the renal, cardiac and splenic tissues of Oncorhynchus mykiss. Methods: 300 fish (Oncorhynchus mykiss) were divided randomly into three groups (N=100 each), consisting of group, 1 (control), and groups 2 and 3 (experimental), which rec...

Various chemical agents were examined for their radioprotective capability to provide partial protection against radiation injury over the past 50 years. However, no suitable drug has yet been introduced for routine clinical use. In the present study, the radioprotective potential of H2 receptor antagonists was examined in in vivo and in vitro conditions. For this purpose, an in vivo micronucle...

The concept of genetic susceptibility and interactions between genetic and environmental factors of risk is a new trend in molecular epidemiology studies of cancers. Micronuclei are biomarkers of chromosome damage due to genetic instability or exposure to environmental mutagens or carcinogens. The micronucleus assay in combination with fluorescent in situ hybridization discriminates between mic...

Micronucleus is similar to the nucleus, but smaller, formed in the cell due to damage of chromosomes by external factors. Incidence of micronuclei is scored in different cell lines as a parameter to evaluate the genotoxicity of chemicals and radiation. Bone marrow micronucleus assay in rodents, particularly in mice, has been the most popular technique used to screen the chemicals for their toxi...

OBJECTIVE A previous study by our research group evaluated the levels of DNA damage using the comet assay in hemodialysis patients with type 2 diabetes mellitus. The same blood samples were also evaluated using the cytochalasin B micronucleus assay. A comparison of the results of the two assays is presented here. METHODS Whole blood samples were collected from 22 type 2 diabetes mellitus pati...

Modern biomedical science has proven beneficial effects of curcumin as potential therapeutic candidate for various conditions due to its pleiotropic and pharmacological properties. The aim the present study was investigate antigenotoxic against cisplatin induced genotoxicity well antioxidative effects. In vitro cytokinesis block micronuclei assay in human lymphocytes used evaluation properties ...

Background & Objective: Micronucleus assay of buccal mucosa cells is a simple bio- monitoring method for diagnosing the genetic damages of toxic agents. The aim was to study the genotox...