Lanosterol is a precursor for cholesterol, which synthesized primarily in the liver pathway often described as mevalonate or HMG-CoA reductase pathway. The first two steps (formation of acetoacetyl CoA and mitochondrial generation (S)-3-hydroxy-3-methylglutaryl-CoA) are also associated with oxidation fatty acids.

In this research, we investigated the cytotoxic mechanisms of Cochlodinium polykrikoidescell lysate on isolated rat liver hepatocytes.This micro algae is responsible for a severe and widespread harmful algal bloom in the Persian Gulf and Gulf of Oman (2008-2009). Isolated hepatocytes were obtained by collagenase perfusion of Sprague-Dawley rat liver.According to our results, incubation of algal...

Depleted uranium (DU) is an important by product in uranium enrichment process. Due toits applications in civilian and also military activity, DU emerged as environmental pollutant.The exposure to DU can occur via external or internal pathways. In external exposure, mainlybeta radiation from the decay products contributes to DU toxicity. Internal exposure to DUis more im...

Background: Mitochondria are the most aboudent and small essential organelles found in eukaryotic cells. These are semiautonomous organelles for the production of cellular ATP that through its various biochemical pathways. The primary pathway for ATP production is OXPHOS via the electron transfer chain (ETC) which is encoded by nuclear DNA and mtdna genomes. Mitochondria consist of double stran...

Introduction: Neurodegenerative diseases are progressive disorders that could impair neuronal functions and structures. Oxidative stress and mitochondrial dysfunction are involved in the etiology of neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease and etc. Gemfibrozil is used as a therapeutic drug for hyperlipidemia. It has been shown that gemfibrozil is n...

Depleted uranium (DU) is an important by product in uranium enrichment process. Due toits applications in civilian and also military activity, DU emerged as environmental pollutant.The exposure to DU can occur via external or internal pathways. In external exposure, mainlybeta radiation from the decay products contributes to DU toxicity. Internal exposure to DUis more im...

Objective(s): Hyperuricemia is a risk for cardiovascular and metabolic diseases, but the mechanism is ambiguous. Increased intestinal permeability is correlated with metabolic syndrome risk factors. Intestinal epithelial cells play a pivotal role in maintaining intestinal permeability. Uric acid is directly eliminated into intestinal lumen, however, the mechanism and e...

Osteosarcoma (OS), a severe malignant bone tumour, usually occurs in adolescents and children has poor prognosis. Asiatic acid (AA), an active component isolated from Centella asiatica (L.) Urb., exhibits appreciable anti-oxidant anti-tumour activities. So far, the effects underlying mechanisms of AA against OS have not been clarified. Here, we explored human involved mechanism mediating its ac...

in this research, we investigated the cytotoxic mechanisms of cochlodinium polykrikoidescell lysate on isolated rat liver hepatocytes.this micro algae is responsible for a severe and widespread harmful algal bloom in the persian gulf and gulf of oman (2008-2009). isolated hepatocytes were obtained by collagenase perfusion of sprague-dawley rat liver.according to our results, incubation of algal...