objective(s) opioid abuse is still remained a major mental health problem, a criminal legal issue and may cause ischemic brain changes including stroke and brain edema. in the present study, we investigated whether spontaneously withdrawal syndrome might affect stroke outcomes. materials and methods addiction was induced by progressive incremental doses of morphine over 7 days. behavioral signs...

background: matricaria chamomilla (mc) contains flavonoids such as apigenine which exerts benzodiazepine-like activity, therefore it may be helpful for morphine withdrawal syndrome treatment. in this study the effects of peripheral (ip) injection of mc hydroalcoholic extract was investigated on morphine withdrawal syndrome signs in rats. material &methods;: 24male wistar rats (200-250gr) were a...

      The effect of aqueous extract of Nepata glomerulosa Boiss. aerial parts on morphine withdrawal syndrome was investigated in mice. Dependence was induced by subcutaneous injections of morphine for 3 consecutive days. On day 4, morphine was injected 2 h prior to intraperitoneal injection of naloxone. The number of jumps during a 20 min. period after naloxone injection was considere...

Recent studies have shown that NMDA receptors are involved in the tolerance and dependence to opioids. In addition, it has been reported that ketamine, dextromethorphan and amantadine have antagonistic activity at NMDA receptors. Therefore, this study was conducted to clarify the effect of these drugs on morphine withdrawal syndrome. Morphine dependence was induced by increasing doses of morphi...

Previous pharmacological studies have implicated serotonergic brain systems in opiate withdrawal syndrome. Increased brain 5-HT release is associated with the development of physical dependence to morphine. Specific serotonin reuptake inhibitors, such as fluvoxamine and sertraline reduce the severity of naloxone precipitated opioid withdrawal syndrome. Other studies have shown that 5-HT system ...

PURPOSE To explore the role of calcium in morphine withdrawal syndrome using various agents affecting calcium levels in cytoplasm. METHODS Mice were rendered dependent on morphine by subcutaneous injection of morphine, and withdrawal was induced 4 hours later by injecting the opioid antagonist, naloxone. Mice were observed for 30 minutes for signs of withdrawal, ie, characteristic jumping, hy...

this study was designed to assess the effect of five common anticonvulsant drugs on naloxone-precipitated withdrawal syndrome in morphine-dependent mice. male mice (25-35 g) were made dependent by increasing doses of morphine (30-90 mg/kg). at least three doses of phenytoin, carbamazepine, sodium valproate, lamotrigine and topiramate were injected i.p. to morphine-dependent mice 45 min prior to...

Introduction: Morphine addiction and morphine withdrawal syndrome are the two main problems of today’s human society. The present study has investigated the effects of nicotine on the strength of physical and psychological dependency in single and repeated doses morphine administrated rats. Methods: Male Wistar rats were subjected to morphine consumption with single or frequent dose protocols. ...

effect of otostegia persica on naloxone-induced morphine withdrawal syndrome was studied in male mice. dependence was induced using daily subcutaneous injections of morphine for three days. morphine was injected to mice at doses of 30 and 45mg/kg on day 1 and 60 and 90mg/kg on day 2 (8:00 am and 6:00 pm). on day 3, morphine (90mg/kg) was injected 1h before oral administration and 1.5h before in...