نتایج جستجو برای: mtnr 1a

تعداد نتایج: 31311  

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه سیستان و بلوچستان 1389
الناز بیرجندیان, آدم ترکمن زهی, محمد هاشمی,

هدف: کبد چرب غیر الکلی طیفی از حالات بالینی – آسیب شناختی است که با رسوب قطرات چربی در کبد بیمارانی که سابقه مصرف الکل ندارند ، مشخص می شود . هیپرمتیلاسیون dna در نواحی پروموتر ژن ها نقش مهمی در کاهش بیان ژن های دخیل در بیماری کبد چرب غیر الکلی دارد . هدف از این مطالعه بررسی متیلاسیون پروموتر ژن های gstt1 ، gstp1 ، apoe ، cpt-1a ، mmp-9 و ctla-4 در بیماران مبتلا به کبد چرب غیر الکلی در جنوب شرق...

15 صفحه اول
2012
P Janusz T Kotwicki K Małgorzata A Szulc

Results 558 abstracts were identified, 51 full texts were obtained and 18 were analyzed. The genes polymorphisms with the evidence of association to occurrence or progression of IS were identified. Both the papers confirming or denying genetic background of IS were found. The genes presenting polymorphisms susceptible to be related to IS were as follows: estrogen receptors (ER), melatonin recep...

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پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه سیستان و بلوچستان - دانشکده علوم پایه 1393
سیما شهرکی, آرزو قهقایی,

بیماری آلزایمر یک اختلال عصبی پیش رونده و برگشت ناپذیر است و این بیماری از نگرانی های اجتماعی و اقتصادی در کشورهای توسعه یافته و در حال توسعه است. دو نشانه پاتولوژیکی این بیماری پلاک های بتا آمیلوئیدی خارج سلولی و نوروفیبریلاری تانگلهای درون سلولی است.)40-1amyloid beta (a? حاصل پردازش amyloid precurcer protein (app) است.) ?-casein (?-cnپروتئین شیر می باشد و دارای عملکرد چاپرونی است. این مولکول ...

Journal: :gene, cell and tissue 0
dor mohammad kordi-tamandani department of biology, university of sistan and baluchestan, zahedan, ir iran; genetic of non-communicable diseases research ccenter, zahedan university of medical sciences, zahedan, ir iran; department of biology, university of sistan and baluchestan, p.o. box: 98155-411, zahedan, ir iran. tel: +98-5412452335, fax: +98-5412446565 maryam najafi department of biology, university of sistan and baluchestan, zahedan, ir iran azizall mojahad department of clinical psychology, zahedan university of medical science, zahedan, ir iran

background apo-lipoprotein e (apoe) and carnitine palmitoyltransferase1-a (cpt1-a) genes are well known to be involved in the pathophysiology of psychiatric disorders such as schizophrenia but regarding their cpg island methylation status data is sparse. objectives the aims of the current study were to highlight the effect of the promoter “hypermethylation” in the development of scz. patients a...

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Journal: :iranian red crescent medical journal 0
saam noroozi neurology research center, kerman university of medical sciences, kerman, iran; department of biochemistry, school of medicine, kerman university of medical sciences, kerman, iran mohammad kazemi arababadi immunology of infectious diseases research center, rafsanjan university of medical sciences, rafsanjan, iran; department of laboratory sciences, faculty of paramedicine, rafsanjan university of medical sciences, rafsanjan, iran hossein ali ebrahimi meimand neurology research center, kerman university of medical sciences, kerman, iran gholamreza asadikaram department of biochemistry, school of medicine, kerman university of medical sciences, kerman, iran; neuroscience research center, institute of neuropharmacology, kerman university of medical sciences, kerman, iran; endocrinology and metabolism research center, institute of basic and clinical physiology sciences, kerman, iran; endocrinology and metabolism research center, institute of basic and clinical physiology sciences, kerman, iran. tel: +98-9131406916, fax: +98-3413222048

conclusions this study showed that ifnβ-1a decreased oxidant impacts in ms patients, but had no influence in improving mitochondrial dysfunction. results in the patients group (30 patients), a significant difference was observed in their measured biochemical factors in comparison to the control group (p = 0.001), however, after six months of using ifnβ-1a, only mda was shown in the main (p = 0....

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ژورنال: :مجله پزشکی ارومیه 0
حمید اشرفی بیمارستان امام خمینی (ره) ارومیه، بخش داخلی مغز و اعصاب، تلفن تماس 3447113-0441تلفن همراه 09141415619 رضا بوستانی سازمان اصلی تایید شده: دانشگاه علوم پزشکی ارومیه (urmia university of medical sciences) آرش اشرفی سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (mashhad university of medical sciences)سازمان های دیگر: پزشک عمومی

مقدمه: با وجود پیشرفت­های بسیار زیاد در جنبه های مختلف بیماری مولتیپل اسکروز ( ms ) که مهم­ترین آن معرفی اینترفرون بتا در درمان آن است، جهان پزشکی همچنان با ناشناخته های زیادی در مورد این بیماری روبرو است. متاسفانه اغلب مطالعات انجام شده در مورد این بیماری در کشورهای غربی انجام شده، لذا این مطالعه با هدف تعیین اثر بخشی اینترفرون در بیماران کشور خودمان انجام شده است.   روش کار: بیمارانی که براسا...

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ژورنال: مجله دانشگاه علوم پزشکی شهید صدوقی یزد 2022
Arshadi, Sajad, Azarbayjani, Mohammad Ali, Bagherian, Mahdi, Banaeifar, Abdolali,

Introduction: HIF-1a is an important regulator in response to hypoxia that affects various genes involved in energy metabolism. The aim of this study was to investigate the effect of exercise intensity on HIF-1a gene expression and cardiac TG content in rats with non-alcoholic fatty liver disease. Methods: The present study was performed experimentally on 40 male Wistar rats. Mice were randoml...

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Journal: :iranian journal of neurology 0
mehrdokht mazdeh department of neurology, farshchian hospital, hamedan university of medical sciences, hamedan, iran. ahmad reza mobaien department of infectious diseases and tropical medicine, valiasr hospital, zanjan university of medical sciences, zanjan, iran

background: available evidence shows that tetracycline family has cellular and molecular mechanisms to protect neurons and oligodendrocytes by modulating matrix metalloproteinases. we tried to compare the effectiveness of intramuscular and subcutaneous interferon beta-1a (inf-β1a) in combination with oral doxycycline among patient with relapsing remitting multiple sclerosis (rrms) and secondary...

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Journal: :iranian journal of immunology 0
gholamhossein hassanshahi immunology and hematology departments, medical school, rafsanjan university of medical sciences, rafsanjan, iran mohammad kazemi arababadi immunology and hematology departments, medical school, rafsanjan university of medical sciences, rafsanjan, iran alan james dickson biochemistry department, faculty of life sciences, manchester university, manchester, uk

background: it is now well established that several environmental stress factors cause activation of p38 map kinase and jnk in various cell types to produce chemokines. objective: to investigate the expression of cxc chemokines gro/kc and sdf- 1a in rat's h4 hepatoma cells in response to heat shock, hyperosmolarity and oxidative stress. methods: hepatoma cells were maintained in mem medium...

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Journal: مجله دانشکده پزشکی دانشگاه علوم پزشکی تهران 2018
Amir Hossein Faghihi, Arash Sarveazad, Asrin Babahajian, Farnaz Farsi, Mansour Bahardoust, Marjan Mokhtare, Seyed Ali Hashemi Kiapay, Shahram Agah,

Background: One of the most important causes of chronic liver disease is hepatitis C virus (HCV), which causes liver cirrhosis and hepatocellular carcinoma. To control the prevalence of the disease, knowledge and information in risk factor of HCV are required. The aim of this study was to compare the risk factors of infection between HCV patients with genotypes 1a and 3a. Methods: This is an o...

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