Allergic rhinitis in children is not an uncommon disease in India. Our objective was to evaluate the effect of allergic rhinitis on nasal mucociliary clearance. The nasal mucociliary clearance time (NMC) was studied using Andersen’s saccharin method in fifty controls and fifty age and sex matched patients of allergic rhinitis. The nasal mucociliary clearance time in healthy controls was found t...

Nasal mucociliary clearance is a primary physiological defense mechanism of upper as well as lower respiratory tract, and thus maintains the state of health of the respiratory tract. Any disturbance in number or movement of cilia and change in character or amount of mucus production leads to an altered nasal mucociliary clearance. The present study was undertaken to study the effect of aging on...

BACKGROUND Lung mucociliary clearance rates are reduced during sleep in patients with asthma. Methylxanthines and beta 2 agonists have been shown to enhance rates of lung mucociliary clearance. This study examined whether oral slow release bronchodilators may also have an effect on this clearance mechanism during sleep in patients with asthma. METHODS Nine patients with asthma with a mean(SE)...

Mucociliary clearance was measured in four patients with chronic autonomic failure and normal ventilatory function using a method of scanning the clearance of inhaled polystyrene particles tagged with 99mTc. Previous surgical and experimental evidence has suggested that autonomic denervation might be expected to impair clearance. However, the four patients in this study showed no significant di...

To assess mucociliary clearance in patients with tracheobronchoplasty, radioaerosol inhalation scanning was performed in 14 patients. The unilateral total lung clearance curve was fitted into two compartmental curves, fast and slow, by least-squares techniques in order to assess mucociliary clearance of the bronchial tree quantitatively. Half-time (T 1/2) of the curve resulting from the subtrac...

Thirty-four children with clinically and radiologically confirmed adenoid hypertrophy underwent otoscopy, impedance tests, active anterior rhinomanometry and nasal mucociliary clearance evaluation before and 6 months after adenoidectomy. Mucociliary clearance velocity increased significantly while binasal resistances decreased after surgery. The authors conclude that mucociliary evaluation and ...

Mucociliary clearance is an important primary innate defense mechanism that protects the lungs from deleterious effects of inhaled pollutants, allergens, and pathogens. Mucociliary dysfunction is a common feature of chronic airway diseases in humans. The mucociliary apparatus consists of three functional compartments, that is, the cilia, a protective mucus layer, and an airway surface liquid (A...

Despite the in vitro ciliotoxicity of tobacco smoke and the abnormal mucociliary clearance found in smoking related chronic bronchitis, studies of mucociliary clearance in healthy smokers have produced variable results. The nasal mucociliary clearance of saccharin and the in vitro nasal ciliary beat frequency were studied in healthy smokers and non-smokers. One of 29 smokers had a nasal mucocil...