tracheomegaly or tracheobronchomegaly is a rare syndrome which is characterized by dramatic dilatation of the trachea and the major bronchi. this syndorme is usually associated with chronic respiratory infection and airway obstruction. in this paper, a case with tracheomegaly and bronchiectasis was scrutinized.

the nasal cavity possesses many advantages as a site for drug delivery, such as, ease of administration, applicability for long term treatments and a large surface area for absorption. one important limiting factor for nasal drug delivery is the limited time available for absorption within the nasal cavity due to mucociliary clearance. several drug delivery systems including different kinds of ...

The nasal mucociliary clearance time was studied using Andersen saccharin method in 50 normal children and 50 age and sex matched patients of adenotonsillar hypertrophy, which was repeated one month after adenotonsillectomy. The normal mucociliary clearance time in healthy children was found to be 8.55 +/- 2.11 minutes. A significant impairment in nasal mucociliary clearance time was noted in c...

Dehydration of the apical surface of cystic fibrosis (CF) airway epithelia leads to a greatly impaired mucociliary clearance function in CF patients. In an in vitro cell model of human airway epithelia taken from CF patients and cultivated for 60 days, mucociliary clearance was zero. Tyloxapol, a synthetic surfactant, is able to restore the mucociliary clearance of the CF epithelia. The velocit...

Dehydration of the apical surface of cystic fibrosis (CF) airway epithelia leads to a greatly impaired mucociliary clearance function in CF patients. In an in vitro cell model of human airway epithelia taken from CF patients and cultivated for 60 days, mucociliary clearance was zero. Tyloxapol, a synthetic surfactant, is able to restore the mucociliary clearance of the CF epithelia. The velocit...

The saccharin test was carried out in a randomly selected sample of schoolchildren (142 boys and 153 girls, age range 11-14 years) to determine the variability and reproducibility of the test and to assess whether it could be used as a screening test for nasal mucociliary clearance. Nasal mucociliary clearance times were analysed according to clinical history (asthma, rhinitis, asthma with rhin...

BACKGROUND Mucociliary clearance is an important component of pulmonary defence. Maximum clearance is thought to depend on an optimal depth of the sol layer, allowing the most efficient interaction between the cilia and the overlying mucus layer. Sodium absorption, the major ion transport in human airways, is thought to be important in the regulation of the depth of the sol layer. In the airway...

1. Nasal and bronchial mucociliary clearance have been studied in ten non-smokers (aged 19-23 years). Nasal mucociliary transport was evaluated by measuring the transport rate of a single radioactive (99mTc) particle deposited on the nasal mucosa. Bronchial clearance was measured after inhalation of insoluble radioactive anionic particles (diameter 7.4 +/- 1.5 micrometer). The initial depositio...