conclusions sequence and structural diversity of the 3'utr variable region and poly u/uc region found in the local isolates indicate specificity in the regulating elements of 3'utr that might be associated with differential replication efficacy of the hcv pakistani isolates. the study necessitates functional characterization of these regulating elements to elucidate variable viral eff...

Phylogenetic analysis has entered the genomics (multilocus) era. For less experienced researchers, conquering large number of software programs required for a multilocus-based phylogenetic reconstruction can be somewhat daunting and time-consuming. PhyloSuite, with user-friendly GUI, was designed to make this process more accessible by integrating multiple needed multilocus single-gene phylogen...

The usual approach to characterizing and estimating multilocus associations in a diploid population assumes that the population is in Hardy-Weinberg equilibrium. The purpose of this study is to develop a set of summary statistics that can be used to characterize and estimate the multilocus associations in a nonequilibrium population. The concept of "zygotic associations" is first expanded to fa...

Phylogeny estimation is extremely crucial in the study of molecular evolution. The increase in the amount of available genomic data facilitates phylogeny estimation from multilocus sequence data. Although maximum likelihood and Bayesian methods are available for phylogeny reconstruction using multilocus sequence data, these methods require heavy computation, and their application is limited to ...

If variation in azole resistance is due to inherent differences in strains of Candida albicans, as a predominantly clonal organism, then correlation between multilocus genotypes and drug resistance would be expected. A sample of 81 clinical isolates from patients infected with human immunodeficiency virus in Toronto, Canada, plus 3 reference isolates were genotyped at 16 loci, distributed on al...

Background and Aim: Staphylococcus aureus pseudintermedius are widespread skin mucous membrane colonizers may cause opportunistic infections in humans animals. This study aimed to identify characterize methicillin-resistant S. (MRSA) (MRSP) isolates from domestic stray dogs cats pet owners Malaysia using molecular epidemiology antimicrobial profiling. Materials Methods: Three hundred fifty oral...

Homozygosity mapping is a very powerful method for mapping rare recessive diseases in humans. In many applications, it is often desirable to compute prior (or unconditional) multilocus probability of autozygosity for inbred pedigrees. This paper proposes a simple yet powerful method for computing the prior multilocus autozygosity probability for complex inbred pedigrees. The method has an added...