In the last decades, many efforts have been made to solve multimodal optimization problems using Particle Swarm Optimization (PSO). To produce good results, these PSO algorithms need to specify some niching parameters to define the local neighborhood. In this paper, our motivation is to propose the novel neighborhood structures that remove undesirable niching parameters without sacrificing perf...

OBJECTIVE The aim of the study was to examine the effectiveness of an intensive inpatient three-week multimodal therapy. We focused especially on the impact on the multimodal therapy outcome of the pre-admission number of treatment types patients had received and of medical specialist groups patients had consulted. METHODS 155 patients with chronic low back pain and indication for multimodal ...

BACKGROUND Research shows that trauma-focused therapy and multimodal interventions are the two most often used strategies in treatment of refugees suffering from posttraumatic stress disorder (PTSD). While preliminary evidence suggests that trauma-focused approaches may have some efficacy, this could not be established for multimodal interventions. However, it may be that multimodal interventio...

abstract prostate cancer is one of the life threatening disorders of male. although, over the last two decades, a high rate of overdiagnosis, and overtreatment has lowered the incidence rate of prostate cancer, the treatment or prevention strategies are not enough to control the high rate of disease related mortality. current medical treatment approaches include surgery, radiation therapy, chem...

Most patients with chronic pain receive multimodal treatment. There is scant literature to guide us, but when approaching combination pharmacotherapy, the practitioner and patient must weigh the benefits with the side effects; many medications have modest effect yet carry significant side effects that can be additive. Chronic pain often leads to depression, anxiety, and deconditioning, which ar...

Colorectal cancer is a major health problem. More than 1 million patients worldwide are diagnosed annually. It is the 3rd most common cancer type and about half a million people die of the disease each year. Incidence suggests that eating habits, lifestyle, and environmental parameters, beyond genetic background, are responsible for the disease progression. The treatment of rectal cancer has ch...