hydatid disease is endemic in some parts of the world. this disease can occur in any organ. we present a 22-year-old farmer who was suffering from hydatidosis for 4 years. he was admitted to the hospital because of fever, cough, and chest pain in 2004. a chest radiograph revealed multiple nodules in both of lungs. a transthoracic echocardiogram showed cystic lesion in the apex of right ventricl...

Sepsis--a state of systemic bacterial infection--often leads to multiorgan failure and is associated with high mortality despite the recent advances achieved in intensive care treatment. Many of the ill effects of sepsis are attributed to an abnormally enhanced host inflammatory response that leads to neutrophil recruitment and activation involving selectins, a class of adhesion molecules, in t...

Colchicine is a relatively safe medication that is widely used for both prevention and treatment of gout attack. However, serious adverse events, including myoneuropathy and multiorgan failure, have been reported. We report a case of colchicine-induced myoneuropathy in a female kidney transplant recipient who had been taking cyclosporine. She developed gastrointestinal discomfort and paresthesi...

Colchicine has a low therapeutic index. Its toxic effects generally occur at doses ≥ 0.5 mg/kg. We present the case of a 39-year-old female with toxicity following ingestion of 0.28 mg/kg. The patient presented to the emergency department (ED) with severe nausea, vomiting, and abdominal pain following an intentional multidrug ingestion that included colchicine, indomethacin, and zopiclone. Desp...

Clofarabine use has been reported to be safe in previous studies. We report 2 cases of relapsed ALL in children, one of them occurring after bone marrow transplantation. The patients were treated with clofarabine 40 mg/m2, etoposide 100 mg/m2 and cyclophosphamide 440 g/m2. They developed severe toxicity leading to death, with multiorgan failure developing less than 10 days after chemotherapy De...

Amiodarone, a bi-iodinated benzofuran derivative, is widely used for arrhythmias. Many patients benefit from the effectiveness of amiodarone in treating potentially life-threatening arrhythmias. However, amiodarone-induced pulmonary toxicity (APT) is a severe complication. Even after the discontinuation of amiodarone, not only is APT difficult to manage, but there is also a potentially life-thr...

We report a case of severe systemic loxoscelism in a previously healthy young man. This was associated with a Coombs-positive hemolytic anemia, striking leukomid reaction, renal failure, respiratory failure and cardiovascular collapse. This is the first documented case of a renal biopsy in a patient with renal failure after envenomation by the brown recluse spider. Associated systemic toxicity ...

Amyloid light-chain (AL) amyloidosis is a hematological disorder characterized by abnormal proliferation of plasma cell clone producing monoclonal free light chains that misfold and aggregate into insoluble fibrils in various tissues. Cardiac involvement common feature leading to restrictive cardiomyopathy poor prognosis. Current first-line treatments aim at achieving response targeting the clo...