Abstract High-risk medulloblastomas are tumours with a poor survival prognosis (≤ 50%), which currently treated radiation therapy and DNA-damaging chemotherapy. The severe side effects of these treatments, including developmental problems secondary tumours, underscore the need for new treatments reduced toxicity. An attractive target such is Myc-family proteins since high-risk amplify either N-...

The MYC gene which consists of 3 paralogs, C-MYC, N-MYC and L-MYC, is one the most frequently deregulated driver genes in human cancer. Because its high prevalence deregulation causal role cancer formation, maintenance progression, targeting theoretically an attractive strategy for treating As a potential anticancer target, was traditionally regarded as undruggable due to absence suitable pocke...

Background: Colon cancer-associated transcript 2 (CCAT2) is a newly recognized lncRNA transcribed from the 8q24 genomic region. It functions as an oncogene in various types of cancers including breast cancer, in which it affects Wnt/β-catenin pathway. Previous studies have shown a putative interaction between this lncRNA and MYC proto-oncogene. Methods: In the current study, we evaluated t...

Abstract MYC-driven medulloblastomas are highly aggressive childhood brain tumors, however, the molecular and genetic events triggering MYC amplification malignant transformation remain elusive. Here we report that mutations in CTDNEP1, a CTD nuclear-envelope-phosphatase, most significantly enriched recurrent alterations medulloblastomas, define high-risk subsets with poorer prognosis. Ctdnep1 ...

lentinan a polysaccharide from medicinal mushroom i.e lentinus, has been known to have anticancer properties. telomerase activity is not observed in normal healthy cells, whereas in cancerous cells telomerase expression is high. telomerase represents a promising cancer therapeutic target. we investigated the inhibitory effect of lentinan on telomerase reverse transcriptase gene (htert) which is...

objective: breast cancer is the most common cause of cancer-related deaths in women both worldwide and in malaysia. azadirachta indica (a. juss), commonly known as neem, is one of the most versatile medicinal plants that has gained worldwide prominence due to its medicinal properties. however, the anticancer effect of ethanolic neem leaf extract against breast cancer has not been documented. th...

embryonic stem cells (escs) are pluripotent, self-renewing cells. these cells can be used in applications such as cell therapy, drug discovery, disease modelling, and the study of cellular differentiation. in this experimental study embryonic stem cells cultured in the laboratory and were amplified. total rna was extracted from cells and converted to cdna by reverse transcription-polymerase cha...

The release of molecules from injured tissue leads to produce inflammatory response that can result in apoptosis and cell death. Preconditioning (PC) can decrease the inflammatory response, increase neuroprotective mechanism on different levels. So, we investigated the role of PC as a suitable preventative approach in neurodegenerative disease in and inflammatory oncogenic factors in PC12 cells...