Primary or secondary hypogonadism results in a range of signs and symptoms that compromise quality of life and requires life-long testosterone replacement therapy. In this study, an implantable nanochannel system is investigated as an alternative delivery strategy for the long-term sustained and constant release of testosterone. In vitro release tests are performed using a dissolution set up, w...

The influence of long and short polymer chains on the gating properties of nanochannel systems modified with a NIPAAm-co-PBA copolymer have been explored. We not only discovered the negative temperature gating behavior of the NIPAAm modified nanochannel systems for the first time, but also achieve these two fully opposite gating behaviors (negative/positive) on the same platform.

A new type of apo-Tf functionalized nanochannel is developed to achieve the specific and selective binding and unbinding of Fe(3+) in a multiple and reversible manner via a protein-conformation-gating mechanism. This ion-responsive biomimetic nanochannel provides a simple, robust, and promising model for studying other biological processes.

In the nanochannel flow behavior with respect to expand their applications in modern systems is of utmost importance. According to the results obtained in this study, the condition of nonslip on the wall of the nanochannel is not acceptable because in the nano dimensions, slip depends on different parameters including surface roughness. In this study, keeping the side area roughness, deformatio...

In this research, an in-house code which uses the molecular dynamics method to study the flow of different nanofluids in the copper nanochannel and computes the thermo-physicals properties has been developed. The flow of nanofluids has been studied from hydro-thermally viewpoint and temperature jump at the wall has been applied. Parametric study to consider the effect of different parametric su...

Previous work has demonstrated the simultaneous concentration and separation of proteins via a stable ion concentration gradient established within a nanochannel (Inglis Angew. Chem., Int. Ed. 2001, 50, 7546-7550). To gain a better understanding of how this novel technique works, we here examine experimentally and numerically how the underlying electric potential controlled ion concentration gr...

We have developed a new nanochannel fabrication technique using chemical-mechanical polishing (CMP) and thermal oxidation. With this technique, it is possible to control the width, length, and depth of the nanochannels without the need for nanolithography. The use of sacrificial SiO2 layers allows the fabrication of centimeter-long nanochannels. In addition, the fabrication process is CMOS comp...

Like ion channels, nanochannels are known to exhibit curious non-Ohmic current-voltage (I-V) characteristics with an approximate piece-wise constant differential resistance. Using a nanoslot model and a nonequilibrium ion transport theory, we attribute the nonlinear resistance to overlapping double layers inside and an extended polarized layer of space charge outside the nanochannel. The overli...

Several strategies have been developed for the control of DNA translocation in nanopores and nanochannels. However, the possibility to reduce the molecule speed is still challenging for applications in the field of single molecule analysis, such as ultra-rapid sequencing. This paper demonstrates the possibility to alter the DNA translocation process through an elastomeric nanochannel device by ...

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