Morphine administration during pregnancy causes several behavioral abnormalities in offspring animals. In the present study the effects of maternal morphine consumption on development of neural tube in Wistar rats (250-300 g) were investigated. Female rats (n = 8 were crossed with male rats and pregnant ones were treated with oral morphine (0.01, 0.05 and 0.1 mg/ml of water) until the 10th day ...

how to cite this article: talebian a, soltani b, sehat m, zahedi a, noorian a, talebian m. incidence and risk factors of neural tube defects in kashan, central iran. iran j child neurol. summer 2015;9(3):50-56. abstract objective neural tube defects (ntds) are the most common congenital defects of central nervous system due to neural tube closure deficit during the third and fourth weeks of ges...

neural tube defects (ntd) are one of the most important malformations of newborns. the aim of this research is to determine the rates of ntd, anencephaly and spina bifida cystica and the relations of these abnormalities to the factors including sex, race, ethnicity, maternal age and familial marriage in the south-east of the caspian sea border. a three-year descriptive-analytic and cross-sectio...

background: neural tube defects (ntds) including spina bifida and anencephaly are the second most common birth defects with 2.8 per 1000 births in northern iran. objectives: this study was conducted to determine the risk factors of neural tube defects in gorgan, north of iran. patients and methods: this hospital-based, case-control study was carried out on all ntd-affected pregnancies (n = 59) ...

Morphine administration during pregnancy causes several behavioral abnormalities in offspring animals. In the present study the effects of maternal morphine consumption on development of neural tube in Wistar rats (250-300 g) were investigated. Female rats (n = 8 were crossed with male rats and pregnant ones were treated with oral morphine (0.01, 0.05 and 0.1 mg/ml of water) until the 10th day ...

In avian embryos, cranial neural crest cells emigrate from the dorsal midline of the neural tube shortly after neural tube closure. Previous lineage analyses suggest that the neural crest is not a pre-segregated population of cells within the neural tube; instead, a single progenitor in the dorsal neural tube can contribute to neurons in both the central and the peripheral nervous systems (Bron...

F52 is a myristoylated, alanine-rich substrate for protein kinase C. We have generated F52-deficient mice by the gene targeting technique. These mutant mice manifest severe neural tube defects that are not associated with other complex malformations, a phenotype reminiscent of common human neural tube defects. The neural tube defects observed include both exencephaly and spina bifida, and the p...