نتایج جستجو برای: nk cell
تعداد نتایج: 1690878 فیلتر نتایج به سال:
Background and purpose: The aim of this study was to compare the proportion of natural killer (NK) and natural killer T (NKT)-like cells in dyspeptic disorders caused by Helicobacter pylori (H. pylori). Materials and methods: In a case-control study, 27 patients with gastric cancer (GC), 25 patients with peptic ulcer (PUD), and 22 patients with non-ulcer dyspepsia (NUD) were enrolled. After en...
Behcet disease (BD) is a systemic inflammatory disease of the unknown etiology. There is however, some evidence to suggest that immunological abnormalities are important in its pathogenesis, furthermore several T-cell abnormalities which may be quite relevant to autoimmune origin of the disease have been described. We report here our study of T-cell subsets, B and NK cells in 68 patients with B...
background: mature t/ nk-cell neoplasms are a rare group of disorders and their presentation as leukemia is even rarer. most of the previous studies have focused on mature b-cell lineage leukemias and there is a paucity of data on mature t/nk-cell lineage leukemias. we, therefore, planned this study to analyze their spectrum, frequency, morphology and immunophenotypic features. methods: all cas...
immunophenotyping of lymphocytes is very essential for evaluation of immune system. due to the effect of environmental factors and ethnical diversity on immune system, establishment of an internal normal range of lymphocyte subsets is a necessity for each population. the aim of this study was to determine the normal range of t and b lymphocytes, and nk cells in normal i...
background: hla-g is a nonclassical hla class i molecule which, when elevated in tumor cells, is one of the main factors involved in tumor evasion of immune responses including nk and t cells. objective: to evaluate the effect of hla-g downregulation on nk cell cytotoxicity in tumor cell lines. methods: the expression level of hla-g was measured by real-time pcr and flowcytometry after transfec...
Introduction: Functional defect in immune cells is the prominent feature in hematological malignancies that lead to the expansion of tumor cells. Using immunostimulatory cytokines is one of the new therapeutic approaches. This study aimed to investigate the effect of IL-27 on the activity of bone marrow-NK cells of chronic lymphocytic leukemia (CLL) patients in vitro. Materials and Methods: 10 ...
ABSTRACT Natural Killer cells (NKs), are considered an important first line of defence and were originally defined by their ability to kill certain tumor cells and virally infected cells. Our aim is to study expression of HLA class-Ia on tumor cell lines and their susceptibility of NK cells. In this study MDA-MB-468 tumor cell line (NCB1, C208) That derived from human breast adenocarcino...
background: schizophrenia has been associated with altered immunity. different studies regarding natural killer cell activity (nka) in schizophrenic patients have shown inconsistent results. objectives: to evaluate nk cell activity in schizophrenic patients in comparison with healthy control individuals. methods: 30 medication-free schizophrenic patients and 41 healthy sex, age and smoking st...
Natural killer (NK) cells are a subset of lymphocytes which play a crucial role in early innate immune response against infection and tumor transformation. Furthermore, they secrete interferon-γ (IFN-γ) and tumor necrosis factor (TNF) prompting adaptive immu-nity. NK cells distinguish the unhealthy cells from the healthy ones through an array of cell-surface receptors. Human NK cells use inhibi...
Introduction: Immunological processes play an important role in recurrent spontaneous abortion(RSA). According to studies, T lymphocytes and natural killer cells(NK cells) are two effective cell groups in RSA. The aim of this study was to study the percentage and absolute number of natural killer(NK) cells in women with RSA of unknown etiology. Methods: A total of 24 women with history of recu...
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