background: many oral squamous cell carcinomas (osccs) arise within regions that previously had premalignant lesion. early diagnosis and prompt treatment of premalignant lesions offers the best hope of improving the prognosis in patients with oscc. exfoliative cytology is a simple and non-invasive diagnostic technique that could be used for early detection of oral premalignant and malignant les...

To study the appearance and distribution of the normal mucosa at the gastroduodenal junction in man, 14 specimens of normal mucosa, eight obtained during pylorplasty, and "relatively" normal specimens from the distal stomach and whole duodenum were examined microscopically. Three histologically distinct types of normal duodenal mucosa were found at this junction. These were termed antral type d...

introduction: leukoplakia is the most common precancerous lesion of the oral mucosa and may range microscopically form benign hyperkeratosis to invasive squamous cell carcinoma. p53 is a tumor suppressor protein; whereas, proliferative cell nuclear antigen (pcna) is a proliferative marker. the aim of this study was to evaluate the immunohistochemical expressions of p53 and pcna in oral leukopla...

Background: Recent researches have provided evidences of the importance of endothelin axis in carcinogenesis. According to our knowledge, no data exists about endothelin A receptor (ETA) expression in dysplastic oral mucosa (DOM). Therefore, the aim of the present study was to evaluate immunohistochemical expression of ETA in DOM. Methods:</strong...

Lichen planus (LP) is a chronic inflammatory disease of probable immune-based etiology. The pathogenesis of LP is unclear, but apoptotic changes in epidermal (epithelial) cells have been reported. Destruction of the basal cell layer is observed and many changes in cell proliferation, cell repair and cell death occur in the injured mucosal epithelium. The aim of this study was to evaluate and co...