Silver nanoparticles (Ag-nps) have been widely used in various biomedical products. Compared with its hazardous effects extensively being studied, rare attention has been paid to the potential protective effect of Ag-nps to human health. The present study was designed to evaluate the protective effects of Ag-nps and heat shock treatment on tumor necrosis factor-α (TNF-α)-induced cell damage in ...

PURPOSE Combination therapy is increasingly used as a primary cancer treatment regimen. In this report, we designed EGFR peptide decorated nanoparticles (NPs) to co-deliver docetaxel (DTX) and pH sensitive curcumin (CUR) prodrug for the treatment of prostate cancer. RESULTS EGFR peptide (GE11) targeted, pH sensitive, DTX and CUR prodrug NPs (GE11-DTX-CUR NPs) had an average diameter of 167nm ...

To develop amphotericin B-loaded biodegradable TPGS-b-(PCL-ran-PGA) nanoparticles (PLGA-TPGS-AMB NPs) for fungal infection treatment, PLGA-TPGS NPs and PLGA NPs were synthesized by a modified double emulsion method and characterized in terms of size and size distribution, morphology and zeta potential. Drug encapsulation efficiency, in vitro drug release, and in vitro/vivo tests against Candida...

BACKGROUND Use of engineered nanoparticles (NPs) in consumer products is resulting in NPs in drinking water sources. Subsequent NP breakthrough into treated drinking water is a potential exposure route and human health threat. OBJECTIVES In this study we investigated the breakthrough of common NPs--silver (Ag), titanium dioxide (TiO2), and zinc oxide (ZnO)--into finished drinking water follow...

Abstract. Cancer is a major health problem all over the world. Photo thermal therapy (PTT) is a non-invasive method in cancer treatment. In PTT, the laser light usually in near-infra red region is absorbed and converted to heat in the cancerous tissue. The temperature above 40 ° C in PTT can induce some effects including irreversible damage to proteins, changes in enzyme struc...

the aim of this study was to examine the adverse effects of zinc nanoparticles on hematological indices of trout and investigate the improvement of these indices after vitamin c treatments. this study assesses the protective role of vitamin c in fish exposed to zno nps. two concentrations of zno-nps (40 and 80 mg l-1) and two doses of vitamin c (400 and 800 mg per kg of feed) were used to treat...

background: in recent years, nanoparticles have been increasingly used in industries. however, there is a serious lack of information concerning their impact on human health and the environment. this study was investigated the effect of moo3 nps on thyroid hormones in female rats. methods: in this study, 21 female wistar rats were selected and divided into three groups of untreated control, sha...

The quest for early detection and treatment of diseases has led to intense research on theranostics [1]. With diagnosis and therapy combined onto a single platform, theranostics enables real-time monitoring of the status of disease treatment and allows for timely adjustment of type and dose of drugs, paving the way towards personalized medicine. The unique physiochemical properties of nanoparti...

Biotin molecules could be used as suitable targeting moieties in targeted drug delivery systems against tumors. To develop a biotin targeted drug delivery system, we employed human serum albumin (HSA) as a carrier. Methotrexate (MTX) molecules were conjugated to HSA. MTX-HSA nanoparticles (MTX-HSA NPs) were prepared from these conjugates by cross-linking the HSA molecules. Biotin molecules were...

Copper nanoparticles (Cu-NPs) are components in numerous commercial products, but little is known about their potential hazard in the marine environments. In this study the effects of Cu-NPs and soluble Cu on juvenile Epinephelus coioides were investigated. The fish were exposed in triplicate to control, 20 or 100 µg Cu L(-1) as either copper sulphate (CuSO4) or Cu-NPs for 25 days. The growth p...