Hydroxyurea is an effective com[»undin inhibiting the growth of a transplantable mammary tumor (HMC) in the Fischer rat, the inhibition being dose related and independent of the duration of treatment. Several compounds related to hydroxyurea were tested and compared to the parent compound. 1-Ethyl-lhydroxy urea and 1-methyl-l-hydroxyurea are more effective than hydroxyurea in causing inhibitio...

Hydroxyurea is an effective com[»undin inhibiting the growth of a transplantable mammary tumor (HMC) in the Fischer rat, the inhibition being dose related and independent of the duration of treatment. Several compounds related to hydroxyurea were tested and compared to the parent compound. 1-Ethyl-lhydroxy urea and 1-methyl-l-hydroxyurea are more effective than hydroxyurea in causing inhibitio...

Nucleic acids are involved in the most important processes occurring in living cells and possess an enormous potential for specific interactions with different biopolymers. Specificity of recognition of DNA and RNA species by complementary nucleic acids is unique in the world of biopolymers. A great number of the proteins involved in processes of replication, transcription, and translation are ...

Recent studies on the fate of labeled dietary purines in the rat have shown t,hat dietary adenine is a precursor of t,he adenine and of the guanine of tissue nucleic acids (l), but that guanine (2), hypoxanthine (3), and xanthine (3) are not utilized for nucleic acid synthesis. Similar experiments have shown that the pyrimidines, uracil, thymine (2), and cytosine (4) are not incorporated into t...