Skin wound healing has been the subject of extensive studies and various drugs have been used in an attempt to improve wound healing. There are conflicting data regarding the effects of L-arginine, the substrate of nitric oxide, on wound healing. We examined the 1-week rate of cutaneous wound healing and collagen deposition in three groups of rats who received a (1) L-arginine (2% in drinking w...

The skin is densely innervated with an intricate network of cutaneous nerves, neuromediators and specific receptors which influence a variety of physiological and disease processes. There is emerging evidence that cutaneous innervation may play an important role in mediating wound healing. This review aims to comprehensively examine the evidence that signifies the role of innervation during the...

abstract background: the incidence of early wound related complications is assessed in laparoscopic versus open abdominal surgeries. complications of surgical wounds (esp. wound infections) are considered as a major problem in surgery wards. complications of surgical wounds are classified as early and late. common and early complications are hematoma, seroma and wound infection. methods: the me...

  Background and Objective: Angiogenesis is a complex program of several steps and it is tightly regulated by pro- and anti-angiogenic factors. Angiogenesis is one of the key elements in cutaneous wound healing and skin cancers. Estrogen seems to have positive modulating effect on cutaneous wound healing and this effect may be explained by its angiogenic properties. This study aims to investig...

background: wound complications following open repair for acute achilles tendon ruptures (aatr) remain the subject of significant debate. the aim of this study is to investigate the effects of covering repaired aatr using well-nourished connective tissues (paratenon and deep fascia) to avoid complications after open repair.   methods: in this case series study, open repair was performed for 32 ...

Summary Background Myiasis is an infestation of neglected open wounds by fly larvae. Global warming, related climate changes, and increased traveling in tropical countries may contribute to the worldwide diffusion new species. Common risk factors for myiasis are advanced age, poor hygiene, malnourishment, social isolation, diabetes, cancer, peripheral artery disease. The aim this study was revi...

BACKGROUND Kruppel-like factor KLF4 is a transcription factor critical for the establishment of the barrier function of the skin. Its function in stem cell biology has been recently recognized. Previous studies have revealed that hair follicle stem cells contribute to cutaneous wound healing. However, expression of KLF4 in hair follicle stem cells and the importance of such expression in cutane...

BACKGROUND Nitric oxide (NO) deficiency contributes to diabetic wound healing impairment. The present study tested the hypothesis that increased cutaneous superoxide (O2-) levels in type 1 diabetic mice cause NO deficiency and delayed wound healing. METHODS AND RESULTS Wound healing was markedly delayed in streptozotocin-induced type 1 diabetic mice compared with the normal controls. There we...