from december 2000 until 2010, the researchers at royan institute conducted a wide range of investigations on ovarian tissue cryopreservation with the intent to provide fertility preservation to cancer patients that were considered to be candidates for these services. in 2010, royan institute established the royan human ovarian tissue bank as a subgroup of the embryology department. since its i...

In women, around 10% of cancers occur in those younger than 45 years old. Although aggressive chemotherapy/radiotherapy and bone marrow transplantation can cure more than 90% of girls and young women affected by disorders requiring such treatment, the ovaries are very sensitive to cytotoxic drugs, especially to alkylating agents. Therefore, these treatments can result in premature ovarian failu...

From December 2000 until 2010, the researchers at Royan Institute conducted a wide range of investigations on ovarian tissue cryopreservation with the intent to provide fertility preservation to cancer patients that were considered to be candidates for these services. In 2010, Royan Institute established the Royan Human Ovarian Tissue Bank as a subgroup of the Embryology Department. Since its i...

Background: Ovarian tissue cryopreservation is an alternative strategy to preserve the fertility of women predicted to undergo premature ovarian failure. This study was designed to evaluate the expression of folliculogenesis-related genes, including factor in the germline alpha (FIGLA), growth differentiation factor-9 (GDF-9), follicle-stimulating hormone receptor (FSHR), and KIT LIGAND after v...

Background: The functional longevity of ovarian transplant at present is one of the most challenging questions regarding ovary transplantation. So, we used hyaluronic acid (HA) hydrogel scaffold with combination of VEGF and bFGF for restoration of cyclical ovarian function after ovarian tissue transplantation in a rat model. Materials and Methods: A total of 25 Wistar female rats weighing betwe...

oocyte, embryo and ovarian tissue cryopreservation are being increasingly proposed for fertility preservation among cancer patients undergoing therapy to enable them to have babies after the cancer is cured. embryo cryopreservation is not appropriate for single girls without any sperm partner and also because oocyte retrieval is an extended procedure, it is impossible in cases requiring immedia...

Background: Oocyte, embryo and ovarian tissue cryopreservation are proposed for fertility preservation to cancer patients who hope to be mothers after getting rid of the disease. Materials and Methods: Embryo cryopreservation is not possible for unmarried single girls without sperm partner and oocyte retrieval is a long time procedure. Thus ovarian tissue cryopreservation is suggested for ferti...

the capability to preserve human oocytes, blastocysts, ovarian tissue and spermatozoa is an important tool in human assisted reproductive techniques. this preservation allows patients undergoing chemotherapy or radiotherapy to preserve their fertility, and helps to attain all benefits from the costly ovarian superovulation therapies prior to art. the primary goal in establishing an appropriate ...

background: ovarian tissue transplantation is emerging technologies for fertility preservation. in addition, in vitro maturation (ivm) of oocytes retrieved from ovarian tissues may overcome the fertility defects in certain cases. objective: the aim was to evaluate the best site for ovarian tissue transplantation in mice. also, feasibility of ivm of oocytes retrieved from auto grafted ovarian ti...