Arbogast, Sandrine, and Michael B. Reid. Oxidant activity in skeletal muscle fibers is influenced by temperature, CO2 level, and muscle-derived nitric oxide. Am J Physiol Regul Integr Comp Physiol 287: R698–R705, 2004. First published June 3, 2004; 10.1152/ ajpregu.00072.2004.—Free radicals are produced continuously by skeletal muscle fibers. Extracellular release of reactive oxygen species (RO...

oxidative stress has been suggested as a consequence and as a cause of epileptic seizures. researches indicate achillea wilhelmsii (a.wilhelmsii) has anti-oxidant and anti-spasmic effects on central nervous system. this plant grows in most part of iran. an iranian research that done in 2013 showed that the hydroalcoholic extract of achillea wilhelmsii possesses an antioxidant effect in the brai...

Kinsey GR, McHowat J, Beckett CS, Schnellmann RG. Identification of calcium-independent phospholipase A2 in mitochondria and its role in mitochondrial oxidative stress. Am J Physiol Renal Physiol 292: F853–F860, 2007. First published October 17, 2006; doi:10.1152/ajprenal.00318.2006.—Oxidant-induced lipid peroxidation and cell death mediate pathologies associated with ischemiareperfusion and in...

Oxidant-induced lipid peroxidation and cell death mediate pathologies associated with ischemia-reperfusion and inflammation. Our previous work in rabbit renal proximal tubular cells (RPTC) demonstrated that inhibition of Ca(2+)-independent phospholipase A(2) (iPLA(2)) potentiates oxidant-induced lipid peroxidation and necrosis, implicating iPLA(2) in phospholipid repair. This study was conducte...

There is the need for new drugs with better action and lesser side effects. A lot of research is being undertaken to find out new plant drugs, their extraction and pharmacological evaluation. One of such plant is Curcuma aromatica whichbelongs to the genus Curcuma and reported to have high ethno-botanical values in traditional medicine. The present study evaluates comparative pharmacol...

Xanthine oxidase is a key enzyme responsible for hyperuricemia, a pre-disposing factor for Gout and oxidative stress-related diseases. Only two clinically approved xanthine oxidase inhibitors Allopurinol and Febuxostat are currently used for treatment of hyperuricemia. However, owing to their side effects there is a need for new non-purine-based selective inhibitors of xanthine oxidase. In the ...

Seaweeds have caused an emerging interest in the biomedical area, mainly due to their contents of bioactive substances which show great potential as anti-inflammatory, anti-microbial, anti-viral and anti-tumoral drugs. Despite the diversity in quality and quantity of the Mediterranean Tunisian coast flora, with its large contains of marine organisms and seaweeds, most of them have not yet been ...

antioxidant activities protect the cell against oxidative agents that are constant metabolic by-products. the aim of this study was to investigate the relationship between harvesting time of thymus transcaspicus and its antioxidant activities. the plant samples were harvested 5 times in different growth phases from 17 april to 22 july 2008, and its antioxidant activity was studied using the fer...

Hemoglobin (Hb) has been proposed to be a major pro-oxidant in raw and cooked meats. To understand the mechanisms and differentiate between the pro-oxidant and antioxidant potential of oxyhemoglobin (OxyHb) and methemoglobin (MetHb), their pro-oxidant activity, protein solubility, radical scavenging capacity, iron content and contribution of non-chelatable iron on lipid oxidation were determine...

Background: Diabetes is a metabolic disease that is associated with hyperglycemia and infertility. Previous studies indicate that aloe vera may positively affect the blood glucose and fertility. Objective: the present study was carried out to evaluate effect of aloe vera on serum oxidant/antioxidant activity and reproductive hormones following experimental diabetes. Methods: sixty adults male ...