Strides in information technology and improvements in networking technology have set the pace for rapid growth in new applications of electronic commerce in a variety of settings. Business to business (B2B), business to customer (B2C), customer to business (C2B), and customer to customer (C2C) have become prevalent business channels and have reshaped the ways that business transactions are cond...

Bosentan is a competitive inhibitor of endothelin receptors. In vitro, bosentan potently inhibits binding of endothelin-1 to human ET-A and ET-B receptors. Potency on ET-A receptors was only slightly greater than potency on ET-B receptors. Functionally, bosentan inhibits contractile effects of endothelin-1 in rat aorta and human blood internal mammary artery and vein. Oral administration of bos...

TO THE EDITOR—Two systematic reviews and meta-analyses on the efficacy of tigecycline were performed and published in parallel [1–2]. They have reached similar conclusions, that overall mortality was increased in patients given tigecycline. This difference reached significance when all studies were included in our systematic review and meta-analysis [1]. In March 2012, Prasad et al [3] publishe...