Parentage testing is an important tool in farm animals for genetically determining the accuracy of pedigree information. The objective of the current study was to implication of multiplexing 14 microsatellite markers for routine parentage testings. The twenty-four lambs were crossbred of Ghazel × Baluchi, Ghazel × Baluchi × Merinos, and Baluchi × Moghani × Merinos breeds. The genomic DNA was ex...

Gene-mapping studies routinely rely on checking for Mendelian transmission of marker alleles in a pedigree, as a means of screening for genotyping errors and mutations, with the implicit assumption that, if a pedigree is consistent with Mendel's laws of inheritance, then there are no genotyping errors. However, the occurrence of inheritance inconsistencies alone is an inadequate measure of the ...

Recent advances in genomics resources and tools are facilitating quantitative trait locus mapping. We developed a crossbreed pedigree for mapping quantitative trait loci for hip dysplasia in dogs by crossing dysplastic Labrador Retrievers and normal Greyhounds. We show that one advantage to using a crossbreed pedigree is the increased marker informativeness in the backcross/F2 population relati...

GMCheck uses graphical modeling to find the posterior probabilities of data errors given genotypes or phenotypes in a specified pedigree structure.

Genome screen data collected for linkage analysis can be used to detect pedigree errors. We have developed methods applicable to a broad range of relationships. We discuss applications of our methods to data on asthma, in which we detect a number of likely mis-specified relative pairs. We propose a graphical method for error detection in complex inbred pedigrees, with application to the Hutteri...

Estimated breeding value (EBV) was calculated based on either individual phenotype (SP), an index of individual phenotype and full- and half-sib family averages (SI) or Best Linear Unbiased Prediction (BLUP). Calculations were done with correct data or data with 5, 10, 15 or 20% of the records per generation containing pedigree errors. Traits considered were litter size (LS), backfat (BF) and a...

Inferring the haplotypes of the members of a pedigree from their genotypes has been extensively studied. However, most studies do not consider genotyping errors and de novo mutations. In this paper, we study how to infer haplotypes from genotype data that may contain genotyping errors, de novo mutations, and missing alleles. We assume that there are no recombinants in the genotype data, which i...

MOTIVATION Errors in nucleotide sequence and SNP genotyping data are problematic when inferring haplotypes. Previously published methods for error detection in haplotype data make use of pedigree information; however, for many samples, individuals are not related by pedigree. This article describes a method for detecting errors in haplotypes by considering the recombinational history implied by...