The rapid-release mechanisms of standard extract from Ginkgo biloba leaf (EGb) in the polyethylene glycol (PEG) 6000 dispersions were investigated. The apparent equilibrium solubilities of the total flavone glycosides and the soluble solid materials of EGb increased linearly with the increasing concentrations of PEG 6000 solutions. In DSC curves, the peak, onset and endset temperatures of solid...

Aluminium (Al) toxicity and drought are the two major abiotic stress factors limiting common bean production in the tropics. Using hydroponics, the short-term effects of combined Al toxicity and drought stress on root growth and Al uptake into the root apex were investigated. In the presence of Al stress, PEG 6000 (polyethylene glycol)-induced osmotic (drought) stress led to the amelioration of...

The purpose of the study was to increase the dissolution and bioavailability of BCS class II drug, paliperidone by amorphization. The technique that was evaluated for preparing amorphous paliperidone (PAL) was Hot Melt Extrusion (HME). In case of hot melt extrusion process, copovidone was used essentially as a hydrophilic polymer with plasticizers like PEG (6000 and 20000), stearic acid and cet...

Some drugs have low bioavailability due to their poor aqueous solubility and/or slowdissolution rate in biological fluids. Stiripentol (STP) is a novel anticonvulsant drug that isstructurally unrelated to the currently available antiepileptics. It has poor aqueous solubilityand its solubility has to be enhanced accordingly. Polyethyleneglycol 6000 (PEG-6000) iscommonly utilized as a hydrophilic...

<p>Setiaplaboratoriumharusmemberikanhasil yang teliti, cepat dan tepat.Dari total kesalahanlaboratorium 61% merupakankontribusidarikesalahanpraanalitik, kesalahananalitik 25%, kesalahanpascaanalitik 14%. PraAnalitik merupakantahappersiapanawal, tahapini sangat menentukankualitassampel akandihasilkan proses kerjaselanjutnya. Ada duakelompokpraanalitikyaitupraanalitikekstralaboratorium praa...

some drugs have low bioavailability due to their poor aqueous solubility and/or slowdissolution rate in biological fluids. stiripentol (stp) is a novel anticonvulsant drug that isstructurally unrelated to the currently available antiepileptics. it has poor aqueous solubilityand its solubility has to be enhanced accordingly. polyethyleneglycol 6000 (peg-6000) iscommonly utilized as a hydrophilic...

in order to enhance in vitro dissolution and content uniformity of poorly soluble drug glimepiride by preparing solid dispersions using modified solvent fusion method, solid dispersions of drug were prepared by modified fusion solvent method using peg 6000 and pvp k25 (as carrier). eight batches (f1-f8) were prepared by factorial design (23) by taking three factors i.e. the concentration of: dr...

Various tannin-complexing agents have been used to study the potential adverse effects of tannins on rumen metabolism. Using a method based on turbidity formation, the binding of various tannin-complexing agents (polyvinyl polypyrrolidone (PVPP), polyethylene glycol (PEG) of molecular weights 2000 to 35,000, and polyvinyl pyrrolidone (PVP) of molecular weight 10,000, 40,000 and 360,000) to tann...

Penelitian ini bertujuan untuk mendapatkan nanopartikel TiO2 serta penambahan surfaktan Cetyl Trimethyl Ammonium Bromide (CTAB) dan Polietilen Glikol (PEG) -6000 . Dalam penelitian proses pembuatan , –CTAB -PEG-6000 TiO2-CTAB menjadi menggunakan metode sol gel, dari bahan TiCl3. yang diperoleh dikarakterisasi XRD SEM Dari hasil analisis ukuran diameter kristal masing sebesar 30,12 nm ,35,66 ,36...

The bioavailability of sulindac (SDC), a nonsteroidal anti-inflammatory drug, is low due to poor aqueous solubility and poor dissolution rate. For this reason it is necessary to enhance the solubility and enhance dissolution of the drug by dispersing SDC in polyethylene glycols 6000 (PEG 6000) and polyvinyl pyrrolidone 40000 (PVP 40000) matrices using the coevaporation technique. Studying the i...