Sodium valproate and tomato extract have been studied in different experimental models of epilepsy individually. The aim of the present study was to evaluate the effect of lycopene on the antiepileptic effects of sodium valproate against pentylenetetrazol-induced kindling in mice. Swiss albino mice of either sex were randomly divided into 5 groups, with each group containing 8 mice. These group...

Pentylenetetrazol purportedly improves memory in mice. Irwin and Benuazizi (1) suggested that pretrial doses of pentylenetetrazol improve short-term retention, that posttrial doses improve longer-term retention, and that the doses that facilitate retention are much less than those that produce convulsions. We tried to confirm the salient parts of their findings. Our method was similar to theirs...

The so-called anxiolytic and anxiogenic drugs are considered to cause, respectively, increases and decreases in plus-maze open arm exploration, without modifying locomotor activity occurring in the closed arms in an elevated plus-maze when the animals are tested in an illuminated environment. Simply testing animals in the dark also increases open arm exploration, which may be interpreted as an ...

In light of theirclosely related mechanisms of action, and preliminary clinical evidence suggesting that they possess similar efficacies, it has been anecdotally suggested that vigabatrin and tiagabine may prove to be therapeutically indistinguishable. As a result, we have conducted a preclinical comparison of their anticonvulsant profile and mechanism of action. Pentylenetetrazol and maximal e...

objective: previously, analgesic, hypnotic, and anticonvulsant effects have been suggested for rosa damascena (r. damascena). in the present study, possible anti-seizure and neuro-protective effects of hydro-alcoholic extract of r. damascena has been investigated after inducing seizures in rats by pentylenetetrazole (ptz). materials and methods: the rats were divided to five groups: (1) control...

in the present study, the effects of caerulein and cck receptor antagonist< on tolerance to the anti-pentylenetetrazol activity of diazepam has been studied. different doses of diazepam (20, 30, 35, 40 and 50 mg/kg) were administered intraperitoneally for a period of 6 days in order to induce tolerance to diazepam. 48 h after the last dose of diazepam, a test dose of diazepam was tested for ant...

In the present study, the effect of essential oil of the root of Angelica archangelica Linn. was evaluated against electrically and chemically induced seizures. The seizures were induced in mice by maximal electroshock and pentylenetetrazol. The effect of essential oil of the root of Angelica archangelica on seizures was compared with standard anticonvulsant agents, phenytoin and diazepam. The ...

apoptosis plays an important role in many pathological processes of the central nervous system. the neuroprotective effect of periodic fasting (pf) in contrast to severe fasting or starvation has been suggested. however, these beneficial effects seem to depend on the type and duration of the used feeding protocol. this study was designed to evaluate the effects of different pf protocols on the ...