Introduction: Penumbra is an important property of the radiation beam to obtain a suitable margin surrounding the target volume. Therefore, the precise penumbra width determination in stereotactic radiotherapy is necessary for treatment planning. This study aimed to compare the obtained results of penumbra width by in-house and standard circul...

In a search for new genes involved in the regulation of erythropoiesis, we identified murine Penumbra cDNA from a multipotent hematopoietic cell line based on its predominant expression in erythroblasts. Subsequently, we identified the human PENUMBRA from a bone marrow cDNA library. Penumbra is a new member of the tetraspanin superfamily of membrane proteins, many of which are thought to functi...

Context. It is unclear why there a rather sharp boundary in sunspots between the umbra and penumbra. Both regions exhibit magnetoconvection, which manifests penumbral filaments penumbra umbral dots umbra. Aims. Here we compare physical properties of filaments. Our goal to understand how these convective features change across this related rapid increase brightness at umbra-penumbra boundary. Me...

To promote neuroregeneration and angiogenesis is a therapeutic target for the treatment of stroke. Hypoxia-inducible factor-1α (HIF-1α) has pleiotropic effects on neurogenesis, angiogenesis and neuroprotection in central nervous system. In this study we investigated whether HIF-1α treatment promotes the proliferation of ischemia induced neural stem cells (NSCs) and neuroregeneration in penumbra...

In this paper, we present a complete design framework for an adaptive multiple agent fuzzy constraint-based controller (MAFCC) based on fuzzy penumbra constraint processing in each fuzzy constraint subnetwork collaborating with a connected constraint network and its corresponding semantic modeling in a rst-order predicate calculus (FOPC) language, with application to a complex hydraulic system....

BACKGROUND Penumbra characteristics play a significant role in dose delivery accuracy for radiation therapy. For treatment planning, penumbra width and radiation field offset strongly influence target dose conformity and organ at risk sparing. METHODS In this study, we present an analytical and numerical approach for evaluation of the rounded leaf end effect on penumbra characteristics. Based...

Introduction: Stereotactic radiosurgery (SRS) is one of the conformal radiotherapy methods and Gamma Knife is a non-invasive SRS technique to treat intracranial lesions with 201 Co- 60 sources without need to surgery and bleeding. Beam penumbra phenomenon leads to irradiation outside the field and normal tissues. Therefore, considering it is momentous to attain the acceptable t...

BACKGROUND The ability to quickly and efficiently identify the ischemic penumbra in the acute stroke clinical setting is an important goal for stroke researchers and clinicians. Early and accurate identification of potentially salvageable versus irreversibly infarcted brain tissue may enable selection of the most appropriate candidates for early stroke therapies and identify patients who may st...