Dysfunctional uterine bleeding occurs in the absence of any pelvic pathology with disruption of normal patterns of endometrial stimulation. It is diagnosed by exclusion and is found more commonly in women around perimenopausal age and increases till menopause. Diagnosis is by histopathologic examination. Methods: Endometrial biopsies of 100 women in the reproductive and perimenopausal age were ...

To further our understanding of the relation between mood and menopause, the authors examined 1) the association between persistent mood symptoms and menopausal status and 2) factors that increase a woman's vulnerability to an overall dysphoric mood during the early perimenopausal period. The sample consisted of an ethnically diverse community cohort of 3,302 pre- and early perimenopausal women...

A pilot study has ascribed an important role in gallbladder motility and emptying to the perimenopausal period. To assess the effect of this period on gallbladder emptying and cholelithogenesis, 25 women in the perimenopausal period without gallbladder disease were submitted to cholangiography and two ultrasound exams. The time for gallbladder emptying and the presence of cholelithiasis were as...

It has been generally accepted that high density lipoprotein cholesterol (HDL-C) level decreases with menopause in women. However, recent reports show different results. There is very little data concerning perimenopausal women. To verify these findings, lipids and lipoprotein(a) [Lp(a)] levels were compared among pre-, peri- and postmenopausal women of similar mean ages. Postmenopausal women h...

Menorrhagia and polymenorrhea are common complaints of perimenopausal women. Safe, effective, and minimally invasive endometrial ablation can be offered as a permanent non-hormonal treatment option. This article provides information on the basic diagnostic work-up of perimenopausal abnormal uterine bleeding. It also discusses the screening and counseling of patients and treatment outcomes for e...

objective(s):the aim of this open label crossover study was to investigate the effects of nigella sativa on reproductive health and metabolic profile of perimenopausal women in rawang, malaysia.   materials and methods:sixty nine perimenopausal women aged 45 to 65 were allocated into the experimental group treated orally with 1600mg/day of encapsulated pure powdered n. sativa compared to contro...

BACKGROUND Studies suggest that brain-derived neurotrophic factor (BDNF) exerts effects on the neuronal function of hippocampal neurons and increases hippocampal mitogen-activated protein kinase phosphatase-1 (MKP-1) expression, which causes depressive behaviors in rat or mouse. Here we focus on the change of serum MKP-1, BDNF, testosterone (T), and estradiol (E2) levels, in order to test the h...

BACKGROUND Epidemiologic research has shown that perimenopausal contraception is an important medical issue, because women during the perimenopause still need effective contraception. The objective of the study was to assess the contraceptive choices of perimenopausal Turkish women. METHODS This is a descriptive cross-sectional study that in a non - random fashion recruited 202 perimenopausal...

BACKGROUND Major depression is associated with higher plasma levels of positive acute-phase proteins, as well as with lower plasma levels of negative acute-phase proteins. The aim of this study is to examine the levels of acute-phase response proteins and whether these levels are influenced by reproductive hormones and antidepressant medication in the perimenopausal depression. METHODS Sixty-...