Due to the rising global environment protection awareness, recycling strategies that comply with the circular economy principles are needed. Polyesters are among the most used materials in the textile industry; therefore, achieving a complete poly(ethylene terephthalate) (PET) hydrolysis in an environmentally friendly way is a current challenge. In this work, a chemo-enzymatic treatment was dev...

The versatility of Polyethylene terephthalate (PET) as a material with numerous applications in the food industry and its recalcitrance to chemical microbial degradation has recently made it an environmental nuisance. In this study, we applied computational methods ascertain dependence PET nanoplastic (NP) on chain length oligomer. binding affinities NPs novel enzyme Polyester Hydrolase Leipzig...

Alzheimer's disease (AD) is characterized by aggregation of amyloid beta (Aβ) into insoluble plaques. Intermediates, Aβ oligomers (Aβo), appear to be the mechanistic cause of disease. The de facto PET AD ligand, [11C]PIB, binds and visualizes Aβ plaque load, which does not correlate well with disease severity. Therefore, finding a dynamic target that changes with pathology progression in AD is ...

molecular chaperones or amyloid-binding compounds?  perspective on their application as possible therapeutic agents in reduction of cytotoxicity of amyloid oligomers

Alzheimer disease (AD) is an age-related neurodegenerative disorder, characterized histopathologically by the presence of senile plaques (SP), neurofibrillary tangles and synapse loss in selected brain regions. Positron emission tomography (PET) studies of glucose metabolism revealed decreased energetics in brain of subjects with AD and arguably its earliest form, mild cognitive impairment (MCI...

Abstract Alpha-synuclein (a-syn) can aggregate and form toxic oligomers insoluble fibrils which are the main component of Lewy bodies. Intra-neuronal bodies a major pathological characteristic Parkinson's disease (PD). These fibrillar structures act as seeds accelerate aggregation monomeric a-syn. Indeed, recent studies show that injection preformed a-syn (PFF) into rodent brain induce endogeno...

Antibody-mediated imaging of amyloid β (Aβ) in Alzheimer's disease (AD) offers a promising strategy to detect and monitor specific Aβ species, such as oligomers, that have important pathological and therapeutic relevance. The major current limitation of antibodies as a diagnostic and imaging device is poor blood-brain-barrier permeability. A classical anti-Aβ antibody, 6E10, is modified with 10...

Abstract Hydrolysis of cellulose in concentrated phosphoric acid is known to give two distinctive mono-disperse cello-oligomers: the degree polymerization (DP) 7 and 15. To understand formation mechanism monodisperse cello-oligomers, transition DP during hydrolysis was monitored by size-exclusion chromatography combined with multiangle laser-light scattering analyses (SEC/MALLS). The obtained r...