Wider use of pharmacological models would facilitate the development of new drugs for Alzheimer's disease (AD), The two main models currently used are based on the cholinergic and glutamatergic hypotheses of AD, Although they lead to some of the attention and memory impairment observed in AD, they do not fully reproduce the AD pattern. The few studies that used a combination modeling approach, ...

Headaches are common in children and adolescents, and are the most common pain complaint when seeking medical advice. Primary headaches are one of the most common disorders of childhood, with migraine and tension type headache being the most prominent. Treatment strategies for primary headaches vary according to patient’s age, family structure, culture and beliefs, headache diagnosis, and accor...

Molecular imaging using PET provides a unique tool for noninvasively investigating the biochemistry of living organs. The wide range of radiolabeled molecules makes it possible to explore various biochemical, physiologic, and pharmacologic processes in vivo. Because each radiotracer is characterized by its particular kinetic behavior in the human body, the quantification of this behavior is a c...

one of the most common health problems are diseases of the cardiovascular system with a great bulk of disease burden; while a considerable number of cardiac patients undergo cardiac surgery; cardiac surgical procedures with cardiopulmonary bypass (cpb) are nowadays among the top list of surgical procedures. more than half of a century has passed since the introduction of total cardiopulmonary b...

objective: today, medicinal plants are widely used in remedies for several ailments and improvement of human health because of their pharmaceutical properties. this study aimed to document important useful medicinal plants and their medicinal characteristics for treatment of human ailments in the arjan _ parishan protected area in fars province of iran during 2010-2012. materials and methods: d...

Alzheimer's disease (AD) is multisystem and multifactor disease with a long no-symptom stage. We propose that a more effective approach to use fMRI as a still emerging, repeatable, non- invasive neuroimaging tools that can be very useful for evaluating, diagnosis, treatment and drugs- development. We studied 30 articles which published between 2008-2017 that included the effects of different bi...

Dysfunction of β -glucocerebrosidase (GCase) has no hydrolytic activity in patients of Gaucher's disease and increasing the risk factor for Parkinson's disease occurrence. Pharmacological chaperone design has been used to treat with misfolded protein in related disease, which utilized a small compound to cause protein folding correctly. This study employed the world largest traditional Chinese ...

INTRODUCTION Mutations in the gene encoding for acid β-glucosidase (β-glucocerebrosidase, GlcCerase) are seen in Gaucher disease (GD), which give rise to significant protein misfolding effects and result in progressive accumulation of glucosyl ceramide. The main treatment for GD is enzyme replacement therapy (ERT). The iminosugar glycosidase inhibitor N-(n-butyl)-1-deoxynojirimycin (miglustat, ...