نتایج جستجو برای: phosphatidylethanolamines

تعداد نتایج: 2578  

Journal: :The Journal of biological chemistry 2004
Yasuo Okamoto Jun Morishita Kazuhito Tsuboi Takeharu Tonai Natsuo Ueda

Anandamide (N-arachidonoylethanolamine) is known to be an endogenous ligand of cannabinoid and vanilloid receptors. Its congeners (collectively referred to as N-acylethanolamines) also show a variety of biological activities. These compounds are principally formed from their corresponding N-acyl-phosphatidylethanolamines by a phosphodiesterase of the phospholipase D-type in animal tissues. We p...

Journal: :FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006
Xue Li Guan Xin He Wei-Yi Ong Wee Kiang Yeo Guanghou Shui Markus R Wenk

Kainate is a glutamate analog that has been widely used in pharmacological studies of neuronal injury related to ischemic conditions and epilepsy. While altered lipid metabolism has been implicated in kainate action, no study has yet investigated the associated changes in lipid metabolites on a systems scale. Here we describe a mass spectrometry-based approach for profiling of lipid mixtures in...

2016
Paul H. Axelsen Robert C. Murphy Miki Igarashi Stanley I. Rapoport

Polyunsaturated fatty acyl (PUFA) chains in both the ω3 and ω6 series are essential for normal animal brain development, and cannot be interconverted to compensate for a dietary deficiency of one or the other. Paradoxically, a dietary ω3-PUFA deficiency leads to the accumulation of docosapentaenoate (DPA, 22:5ω6), an ω6-PUFA chain that is normally scarce in the brain. We applied a high-precisio...

Journal: :Biochimica et biophysica acta 1982
T D Madden P R Cullis

The structural preferences of mixed lipid systems containing egg yolk or 18:1c/18:1c phosphatidylethanolamine and representative detergents (Triton X-100, deoxycholate, octylglucoside and lyso-phosphatidylcholine) have been examined. It is shown that all these detergents exhibit an ability to stabilize a bilayer organization for the phosphatidylethanolamine at detergent to phosphatidylethanolam...

2011
Jaroslav Pól Veronika Vidová Tuulia Hyötyläinen Michael Volný Petr Novák Martin Strohalm Risto Kostiainen Vladimír Havlíček Susanne K. Wiedmer Juha M. Holopainen

Knowledge of the spatial distribution of lipids in the intraocular lens is important for understanding the physiology and biochemistry of this unique tissue and for gaining a better insight into the mechanisms underlying diseases of the lens. Following our previous study showing the spatial distribution of sphingolipids in the porcine lens, the current study used ultra performance liquid chroma...

2017
Amelia K. Pollard Catharine A. Ortori Reinhard Stöger David A. Barrett Lisa Chakrabarti

Functionality of the lipid rich mitochondrial organelle declines with increased age. Recent advances in lipidomic technologies allowed us to perform a global characterisation of lipid composition in two different tissue types and age ranges. Ultra-high performance liquid chromatography coupled with high resolution mass spectrometry was used to establish and compare mitochondrial lipidomes of br...

2016
Mette M. B. Nielsen Kate L. Lambertsen Bettina H. Clausen Morten Meyer Dhaka R. Bhandari Søren T. Larsen Steen S. Poulsen Bernhard Spengler Christian Janfelt Harald S. Hansen

Focal cerebral ischaemia has an initial phase of inflammation and tissue injury followed by a later phase of resolution and repair. Mass spectrometry imaging (desorption electrospray ionization and matrix assisted laser desorption ionization) was applied on brain sections from mice 2 h, 24 h, 5d, 7d, and 20d after permanent focal cerebral ischaemia. Within 24 h, N-acyl-phosphatidylethanolamines...

Journal: :Biochimica et biophysica acta 1992
F L Hoch

Evidence is discussed for roles of cardiolipins in oxidative phosphorylation mechanisms that regulate State 4 respiration by returning ejected protons across and over bacterial and mitochondrial membrane phospholipids, and that regulate State 3 respiration through the relative contributions of proteins that transport protons, electrons and/or metabolites. The barrier properties of phospholipid ...

Journal: :Physical chemistry chemical physics : PCCP 2005
Martina Dyck Peter Krüger Mathias Lösche

Subtle differences in the molecular conformation of fully hydrated phospholipids, and in their interaction with the water reservoir, were assessed as functions of headgroup methylation with surface-sensitive X-ray scattering. To achieve such a structural and functional comparison, diacylphosphatidylethanolamines (PEs) and their mono-, di- and trimethylated (diacylphosphatidylcholine, PC) deriva...

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