High performance liquid chromatography (HPLC) with diode array detection (DAD) and electrospray ionization tandem mass spectrometry (ESI/MS/MS) was used to analyze the main components in the methanol extract of Fructus Aurantii (FA) and the metabolites in rat biological samples after oral administration of the methanol extract of FA. There were 31 constituents identified in the extract of FA in...

Atomoxetine, an attention-deficit/hyperactivity disorder (ADHD) agent , has severe adverse effects, which even causes suicidal ideation in patients and when combined with other drugs such as monoamine oxidase inhibitors or in patients with cardiovascular disorders or pheochromocytoma, it can be fatal. In order to monitor the trough level of the drug, sensitive analytical methods are in demand.T...

Bioanalysis is a chemical analysis used to determine the levels of xenobiotic substances and biotic in biological systems. In pharmaceutical world, bioanalysis plays role development new drugs, monitoring drug therapy, also bioequivalence. The bioanalytic research that will be discussed this journal about dolutegravir urine, saliva (saliva), blood plasma samples. technique can detect content sa...

in this study, simple and efficient ultrasound-assisted emulsification microextraction (usaeme) combined with gas chromatography-flame ionization detector (gc-fid) was developed for the preconcentration and determination of carbamazepine in biological samples. in this method, the fine droplets of 1-octanol were formed and dispersed in the sample with the help of ultrasonic waves, which accelera...

polyoma virus nephropathy occurs in 3% to 4% of renal transplant recipients, causing graft loss in 50% of cases. the objective of the present study was to explore the effects of age, sex, post-transplantation period and plasma creatinine levels on the polyoma virus infection in kidney transplanted patients. urine samples were collected from 362 patients, centrifuged and microscopic slides prepa...

the interaction of sulfur mustard with aminoacids and proteins has been investigated in this study. rats were injected with sublethal doses of sulfur mustard subcutaneously and intraperitoneally. at different time intervals, plasma and urine samples were collected. the binding affinity of sulfur mustard with urinary and plasma proteins and enzymes was studied for the first time using non-ideal ...

The interaction of sulfur mustard with aminoacids and proteins has been investigated in this study. Rats were injected with sublethal doses of sulfur mustard subcutaneously and intraperitoneally. At different time intervals, plasma and urine samples were collected. The binding affinity of sulfur mustard with urinary and plasma proteins and enzymes was studied for the first time using non-i...

Polyoma virus nephropathy occurs in 3% to 4% of renal transplant recipients, causing graft loss in 50% of cases. The objective of the present study was to explore the effects of age, sex, post-transplantation period and plasma creatinine levels on the polyoma virus infection in kidney transplanted patients. Urine samples were collected from 362 patients, centrifuged and microscopic slides prepa...