Malaria is an infection sustained by three parasites namely: Plasmodium falciparum, Plasmodium vivax, and Plasmodium ovale. Plasmodium falciparum is the most common and virulent parasite. These parasites are present in different areas of the sub-Saharan African countries and Asia. In 2010, there were an estimated 219 million cases of malaria resulting in 660,000 deaths and, approximately, two-t...

background: aurones are naturally occurring compounds that belong to flavenoids family and have antiplasmodial effects. this study investigated some new aurones derivatives against chloroquine sensitive plasmodium falciparum. here we report the synthesis , in vitro antiplasmodial activity and cytotoxic evaluation of 11 compound from derivatives of (z)-2- benzylidene-4, 6-dimethoxybenzofuran-3(2...

objective: plasmodium falciparum chloroquine resistance is a major problem in malaria endemic areas. single nucleotide polymorphisms in pfcrt and pfmdr1 genes are known to be associated with chloroquine resistance in some parts of the world. the major goal of the present study was to detect the five single nucleotide polymorphisms in pfmdr1 gene and one single nucleotide polymorphisms in pfcrt ...

background genetic diversity has provided plasmodium falciparum with the potential capacity of avoiding the immune response, and possibly supported the natural selection of drug or vaccine-resistant parasites. merozoite surface protein-3 (msp-3) has been used to develop vaccines and investigate the genetic diversity regarding p. falciparum malaria in iran. objectives the main goal of this study...

background : plasmodium falciparum infection is endemic in most tropical countries and will definitely infect human immunodeficiency virus (hiv) positive patients living in this region at one time or the other during the course of their infection. this study was conducted to determine the prevalence of malaria infection in hiv-infected patients on highly active antiretroviral therapy in benin c...

glomerular involvement occurs as a rare form of renal manifestation in plasmodium falciparum malaria. here, we report a rare case of falciparum malaria-associated iga nephropathy. a 28-year-old man was admitted because of fever and abdominal pain. ultrasound and computed tomography (ct) showed right kidney pyonenphrosis. despite placing a nephrostomy tube, fever continued. repeated ct was in fa...

using mutation specific pcr assay and analysis of position 108 amino acid in dihydrofolate reductase-thymidilate synthase gene in 70 plasmodium falciparum isolates of malarial patients from southern areas of iran, showed 4 different situations: iwild type (108-ser) ii-mutant type (108-thr) iii-mutant type (108-asn) and iv-mixed wild and mutant type (108-ser+thr) with frequency of 58(82.8%), 2(2...