نتایج جستجو برای: platelet storage lesions
تعداد نتایج: 460766 فیلتر نتایج به سال:
Preparations of platelet concentrates (PCs) that are stored under blood bank conditions and used for transfusion purposes, appear to be enriched in platelet derived-microparticles (PMPs) with high coagulant activity that may change platelet efficacy and safety issues. High shear stress could cause shedding of PMPs from the platelet plasma membrane, platelet aggregation, and activation of the co...
Background: Several lines of evidence suggest the role of leukocyte in platelet activation. Since pro-inflammatory mediator CD40 ligand (CD40L) has been considered as a marker of platelet activation that reflecting platelet storage lesion (PSL), we evaluated the effect of leukoreduction processes on thereby the levels of expressed CD40L in Platelet Concentrates (PCs). Methods: In present stu...
Background: Major platelet adhesive receptors that contribute significantly to thrombus formation include platelet receptor glycoprotein Ibα (GPIbα) of the GPIb-IX-V complex and platelet glycoprotein VI (GPVI). GPIbα plays a crucial role in platelet tethering to sub-endothelial matrix, which initiates thrombus formation at arterial shear rates, whereas GPVI is critically involved in platelets f...
background: platelet mps are produced automatically during platelet storage. their size is about 0.1 – 1 µm and have ability for sub- endothelium adhering, strengthen of platelet aggregation and also platelet pre- coagulation. in fact, the release of membrane particles helps to signal to the neighbor cells or to seclude target cells from apoptosis. the purpose of this study is to determine the ...
BACKGROUND AND OBJECTIVES Storage lesions may prevent transfused platelets to respond to agonists and arrest bleeding. The aim of this study was to evaluate and quantify the capacity of platelet activation during storage using flow cytometry and new markers of platelet activation. MATERIALS AND METHODS Activation responses of platelets prepared by apheresis were measured on days 1, 5, 7 and 1...
Background and purpose: Cold storage results in clustering of gpIbα molecules on platelets. Consequently, the lectin domains of αMβ2 receptors on the liver macrophages recognize these molecules and ingest the platelets. Probably coverage of sugar molecules of gpIbα using galactose could prevent the recognition and ingestion of platelets by macrophages. The purpose of this study therby was to...
BACKGROUND The Mirasol Pathogen Reduction Technology system for platelets and plasma uses riboflavin and UV light to introduce irreparable lesions into nucleic acids thereby inhibiting pathogen and white blood cell replication and reducing the load of infectious pathogens. The aim of the present study was to evaluate low plasma buffy coat platelet concentrates obtained from the OrbiSac System a...
blood transfusion centers are under considerable pressure to produce platelet concentrates with a shelf life limit of 3 to 5 days. many approaches have been investigated experimentally to produce new hemostatically active platelet products that are capable of long term storage. in this article infusible platelet membrane will be explained as a platelet substitute versus conventional liquid-stor...
Blood transfusion centers are under considerable pressure to produce platelet concentrates with a shelf life limit of 3 to 5 days. Many approaches have been investigated experimentally to produce new hemostatically active platelet products that are capable of long term storage. In this article infusible platelet membrane will be explained as a platelet substitute versus conventional liquid-stor...
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