BACKGROUND BK polyomavirus-associated nephropathy is an important cause of post-transplantation renal failure. We present two cases of BK polyomavirus-associated nephropathy who were submitted to contrasting strategies of clinical follow-up to BK polyomavirus reactivation, but progressed to a similar final outcome. CASE PRESENTATION Case 1 is a 37-year-old white man whose graft had never pres...

We have investigated the species-specific replication of polyomavirus DNA in the cell-free system that was established previously (Y. Murakami, T. Eki, M. Yamada, C. Prives, and J. Hurwitz, Proc. Natl. Acad. Sci. USA 83:6347-6351, 1986). Extracts from various species of cells supported polyomavirus DNA replication in a species-specific manner that was consistent with the host range specificity ...

Isolation of a strain of polyomavirus, designated COL, from the brain of a patient with progressive multifocal leucoencephalopathy is described. The COL strain is antigenically similar to JC polyomavirus, previously isolated from a brain affected by progressive multifocal leucoencephalopathy and is unrelated to BK, another human polyomavirus isolated from urine. Immunological cross testing of v...

Up to 2007, two human polyomaviruses BK (BKPyV) and JC (JCPyV) were known and named after the initials of the patients where they were first isolated. BKV was isolated from the urine of a kidney transplant patient affected by urethral stenosis [1]. JCV was identified in the brain tissue of a patient with Hodgkin lymphoma who developed a demyelinating disease known as progressive multifocal leuk...

Polyomaviruses infect a diverse range of mammalian and avian hosts, and are associated with a variety of symptoms. However, it is unknown whether the viruses are found in all mammalian families and the evolutionary history of the polyomaviruses is still unclear. Here, we report the discovery of a novel polyomavirus in the European badger (Meles meles), which to our knowledge represents the firs...

BACKGROUND Polyomavirus nephropathy has emerged as an important cause of graft loss in kidney transplant recipients. Polyomavirus rarely affects the native kidneys of an immunocompetent individual. Until now, polyomavirus nephropathy in native kidneys of an immunocompetent individual has not been reported, as far as we know. CASE REPORT A 34-year-old man was transferred from a local clinic to b...

Trichodysplasia spinulosa (TS) is a unique, rare clinical and histological dermatologic entity described mainly in setting of immunosuppression. It caused by novel human polymoavirus, trichodysplasia spinulosa-associated polyomavirus (TSPyV). We report biopsy-proven case TS renal transplant patient presented to dermatology outpatient clinic Montreal, Canada 2015. Reduction immunosuppression and...

Phylogenetic analyses based on the major capsid protein sequence indicate that Merkel cell polyomavirus (MCPyV) and chimpanzee polyomaviruses (PtvPyV1, PtvPyV2), and similarly Trichodysplasia spinulosa-associated polyomavirus (TSPyV) and the orangutan polyomavirus (OraPyV1) are closely related. The existence of cross-reactivity between these polyomaviruses was therefore investigated. The findin...

Phylogenetic analysis of the mammalian and avian polyomaviruses was performed using the most complete set of publicly available polyomavirus genome sequences to date, including the newly discovered MW polyomavirus. There is no evidence for host-switching between mammalian and avian polyomaviruses, but there is extensive evidence for host-switching among mammalian polyomaviruses. Comparative gen...

Forty eight renal transplant recipients were investigated prospectively for evidence of infection with the polyomaviruses BK and JC and cytomegalovirus. An active polyomavirus infection was shown in 31 patients (65%) and cytomegalovirus in 30 (62.5%). Half of the BK and JC virus infections occurred within the first three months after transplantation compared with 93% of the cytomegalovirus infe...