Polyomaviruses may cause human disease, particularly in immunocompromised hosts. JCV, one of the members of polyomaviridae family, is the causative agent of the neurological disease progressive multifocal leukoencephalopathy (PML), which occurs mostly in immunocompromised patients. Progressive Multifocal leukoencephalopathy (PML) is a progressive demyelinating disorder of the central nervous sy...

polyomaviruses may cause human disease, particularly in immunocompromised hosts. jcv, one of the members of polyomaviridae family, is the causative agent of the neurological disease progressive multifocal leukoencephalopathy (pml), which occurs mostly in immunocompromised patients. progressive multifocal leukoencephalopathy (pml) is a progressive demyelinating disorder of the central nervous sy...

Polyomavirus-related infections are ubiqutious in immunocompromised individuals, and some cases intractable fatal. Due to a lack of approved drugs treat polyomavirus infections, cidofovir, phosphonate nucleotide analog cytomegalovirus has been repurposed as an antipolyomavirus agent.

WU polyomavirus is a recently described polyomavirus found in patients with respiratory infections. Of 2,637 respiratory samples tested in St. Louis, Missouri, 2.7% were positive for WU polyomavirus by PCR, and 71% were coinfected with other respiratory viruses. Persistent human infection with WU polyomavirus is described.

Polyomaviruses are known to infect mammals and birds. Deep sequencing and metagenomic analysis identified the first polyomavirus from a cartilaginous fish, the giant guitarfish (Rhynchobatus djiddensis). Giant guitarfish polyomavirus 1 (GfPyV1) has typical polyomavirus genome organization, but is the smallest polyomavirus genome (3.96 kb) described to date.

The number of identified human polyomaviruses (HPyVs) has increased steadily over the last decade. Some novel HPyVs have been shown to cause disease in immunocompromised individuals. Lyon-IARC polyomavirus (LIPyV) belonging species Alphapolyomavirus quardecihominis was 2017 skin and saliva samples from healthy Since its initial discovery, LIPyV rarely detected clinical but faeces cats with diar...

Polyomavirus, discovered by Ludwik Gross as a contaminant in a murine leukemia virus preparation in the early 1950s, was termed polyomavirus by Sarah Stewart and Bernice Eddy because of its ability to elicit multiple different types of tumors in mice. By 1960, culture conditions for growing polyomavirus in vitro had been developed, and its ability to "transform" cells in culture had been establ...

BACKGROUND Polyomavirus BK is a major cause of nephropathy in immunosuppressed transplanted patients. Non-invasive diagnostic protocols such as molecular detection of polyomavirus BK replication are a useful strategy to predict BK virus-associated nephropathy (BKVAN). OBJECTIVE To determine the prevalence of polyomavirus BK infection among kidney transplant patients suspected to have BKVAN. ...

Seventy-two full genomes corresponding to nine mammalian (67 strains) and two avian (5 strains) polyomavirus species were analyzed using maximum likelihood and Bayesian methods of phylogenetic inference. Our fully resolved and well-supported (bootstrap proportions > 90%; posterior probabilities = 1.0) trees separate the bird polyomaviruses (avian polyomavirus and goose hemorrhagic polyomavirus)...

Human polyomaviruses have entered the domain of clinical decision-making in renal transplantation and this has coincided with the use of more potent immunosuppressive regimens. BK polyomavirus has predominated, resulting in nephropathy and ureteral strictures with the potential for graft loss [1]. JCV is a type of human polyomavirus, named with the initials of the patient from whom the virus wa...