نتایج جستجو برای: polyposis colorectal cancer
تعداد نتایج: 932929 فیلتر نتایج به سال:
AIMS AND BACKGROUND Colorectal carcinoma patients from hereditary non-polyposis colorectal cancer families are suggested to have a better prognosis than sporadic colorectal carcinoma cases. Since the majority of hereditary non-polyposis colorectal cancer-related colorectal carcinomas are characterized by microsatellite instability due to germline mutations in DNA mismatch repair genes, this is ...
AIMS Serrated polyposis syndrome is a disease that is often missed in the clinical setting and is associated with colorectal cancer. We investigated the prevalence of SPS and the association between colorectal or other cancers in a 10-year, retrospective data analysis. METHODS We reviewed complete colonoscopy data obtained from January 2005 through January 2015 at a health-screening centre. S...
Familial adenomatous polyposis (FAP) is responsible for <1% of colorectal cancer (CRC) cases and is inherited as an autosomal dominant trait. Patients generally present hundreds to thousands of adenomas and develop colorectal cancer by age 35- 40 if left untreated. Here we report four patients with germline frameshift mutation (small deletion) at exon 15 of adenomatous polyposis coli (APC) tumo...
SUMMARY Our gastrointestinal tract is colonized by trillions of microbes. There growing recognition that commensal bacteria can promote the development colorectal adenomas and cancer. For example, bacterial plaques are strongly associated with in familial adenomatous polyposis (Science 2018;359:592-597), fusobacterium cancer liver metastasis.(Science 2017;358:1443-1448)
The serrated pathway has recently been proposed as a route for the development of colorectal cancer with microsatellite instability. Hyperplastic polyposis syndrome is a rare syndrome defined by the presence of numerous serrated polyps, with a high risk of developing into colorectal cancer. We present here a case of hyperplastic polyposis syndrome developing into colorectal cancer with microsat...
Abbreviations used in this paper: AFAP, attenuated familial adenomatous polyposis; AGA, American Gastroenterological Association; AUC, area under the curve; CI, confidence interval; CRC, colorectal cancer; FAP, familial adenomatous polyposis; HNPCC, hereditary nonpolyposis colorectal cancer; IHC, immunohistochemistry; MAP, MUTYH-associated polyposis; MMR, mismatch repair; MSI, microsatellite in...
Approximately 6% of colorectal cancers can be attributed to recognizable heritable germline mutations. Familial adenomatous polyposis is an autosomal dominant syndrome classically presenting with hundreds to thousands of adenomatous colorectal polyps that are caused by mutations in the APC gene. Adenomas typically develop in the midteens in these patients, and colorectal cancer is a virtual cer...
BACKGROUND Serrated polyposis is a poorly understood and likely underdiagnosed condition. Little is known regarding the colorectal cancer risk, extracolonic phenotype, and cause of serrated polyposis. OBJECTIVE The aim of this study is to describe the clinical and family history features of a large cohort of individuals with serrated polyposis. DESIGN This is a retrospective cohort study fr...
The aim of this study was to assess whether restorative proctocolectomy was suitable as an initial procedure for selected familial adenomatous polyposis patients with coexisting colorectal cancer. Six malignancy patients who underwent restorative proctocolectomy for familial adenomatous polyposis were reviewed. At the time of restorative proctocolectomy, cancer was not suspected in four patient...
بررسی تآثیر کورکومین بر بیان آکواپورین5 در سلول های سرطانی روده بزرگ انسان(ht-29) سرطان روده بزرگ جزو بیماری های خطرناک بوده و از نظر شیوع سومین سرطان شایع و دومین علت مرگ ومیر ناشی از سرطان در جهان محسوب می شود. خطرابتلا به این سرطان تحت تاثیر دو عامل محیطی وفاکتورهای ژنتیکی می باشد. آکواپورین ها، پروتئین های کانال آبی بوده که نقش مهمی را در انتقال آب در بافتهای اندوتلیالی و اپی تلیالی بر عهد...
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