Metformin hydrochloride exhibits poor compressibility during compaction, often resulting in weak and unacceptable tablets with a high tendency to cap. The purpose of this study was to develop directly compressible metformin hydrochloride by the spray-drying technique in the presence of polymer. Metformin hydrochloride was dissolved in solutions containing a polymer, namely polyvinylpyrrolidone ...

geotechnical investigations of waste fills are rarely undertaken, and consequently the geotechnical community has little knowledge of their engineering properties. in this study, a geotechnical testing program was conducted to evaluate the engineering properties of old municipal solid waste sampled in whamyung msw landfill site, busan, korea. the conducted tests included water content, specific...

Nowadays, several medicinal plants are used to produce pharmaceuticals. Nonetheless, development of phytopharmaceutical has intrinsic technological challenges [1]. Concerning to liquid and dry plant extracts, the latter possess many advantages over the former. The chemical and microbiological stability are greater in dry extracts. However, the dry extracts usually show poor physicomechanical pr...

Kobayashi [Kob81] introduced a uniform notion of compressibility of infinite binary sequences X in terms of relative Turing computations with sub-linear use of the oracle. Given f : N → N we say that X is f -compressible if there exists Y such that for each n we can uniformly compute X ↾n from oracle Y ↾ f (n). Kobayashi compressibility has remained a relatively obscure notion, with the excepti...

OBJECTIVE To explore triceps skinfold (TSF) compressibility and its associated factors among hospitalized patients. METHODS A cross-sectional study was conducted among hospitalized adult patients. Evolution of tissue compressibility during two seconds was registered and 120 TSF values were obtained using a digital calliper. Compressibility was determined according to the difference between th...

Analytic expressions were derived for the compressibility factor and residual internal energy of the square-well plus Sutherland fluid. In this derivation, we used the second order Barker-Henderson perturbation theory based on the macroscopic compressibility approximation together with an analytical expression for radial distribution function of the reference hard sphere fluid. These properties...

We exploit recent advances in computational topology to study the compressibility of various proteins found in the Protein Data Bank (PDB). Our fundamental tool is the persistence diagram, a topological invariant which captures the sizes and robustness of geometric features such as tunnels and cavities in protein molecules. Based on certain physical and chemical properties conjectured to impact...