BACKGROUND: Increased dental caries and dental lesions have made preventive measures, especially among children, inevitable. This study investigated elementary schoolgirls’ mothers’ level of knowledge on preventive methods against dental caries. METHODS: In this cross-sectional study, mothers of 250 schoolgirls were randomly selected from five regions of Tehran, Iran. Their knowledge about fiss...

BACKGROUND Isoniazid preventive therapy is a key public health intervention for the prevention of tuberculosis disease among people living with HIV. Despite the confirmed efficacy of isoniazid preventive therapy and global recommendations existing for decades, its implementation remains limited. In resource constrained settings, few have investigated why isoniazid preventive therapy is not impl...

The recognition of tuberculosis (TB) as a major cause of morbidity and mortality among human immunodeficiency virus (HIV)-infected persons has led to renewed interest in TB preventive therapy and its incorporation into the essential package of health care for these individuals. Despite convincing data regarding its efficacy, TB preventive therapy has not been widely implemented. Further work is...

According to the World Health Organization, 1 in every 4 people develops a mental disorder. However, despite the huge efforts in the field, our knowledge about the basic mechanisms of mental disorders is still limited. Although psychiatric medications have been widely prescribed for the past decade, the low efficacy of the treatments, the lack of new validated targets or absence of robust anima...

CONTEXT Isoniazid preventive therapy for latent tuberculosis (TB) infection has been debated because of the risk of hepatotoxicity. The frequency of hepatotoxicity was 0.5% to 2.0% in early studies but may have changed with new criteria for diagnosis and patient selection. OBJECTIVE To determine the rate of isoniazid hepatotoxicity in patients managed according to current guidelines and pract...