The major antimalarial drug quinine perturbs uptake of the essential amino acid tryptophan, and patients with low plasma tryptophan are predisposed to adverse quinine reactions; symptoms of which are similar to indications of tryptophan depletion. As tryptophan is a precursor of the neurotransmitter serotonin (5-HT), here we test the hypothesis that quinine disrupts serotonin function. Quinine ...

Quinine, is an anti-malarial drug that specifically blocks connexin 36 (Cx36) at gap junction channels. Quinine has suppressed ictal epileptiform activity in vitro without decreasing neuronal excitability. Thus, we considered the possible anticonvulsant effects of quinine in the pentylenetetrazole (PTZ) model of seizure. Moreover, we studied the hypnotic effect and locomotor activity of quinine...

To the Edilor, The Indian Medical Gazette. Sir,?Since the coming into existence of the newly organised Punjab Public Health Department in 1923 extensive and elaborate arrangements have been made, from year to year, for the distribution of quinine free of cost for the relief of the malaria-stricken people in almost all the districts of the Punjab. Previously also it was the custom to distribute ...

come across a medical man who avers that it is a useless salt of Quinine and that the only salt of anv use for injection is the Bisulpliate of Quinine, Now, from what I can remember of the Physiology of the Blood, I should have thought that the Bisulpliate was a much more foreign salt to the plasma than the Bihydrochloride. As far as I can remember the plasma contains Chlorides in abundance, bu...

The behavioral effect and acute toxicity of methamphetamine were tested alone and in combination with quinine in rats. Quinine prolonged and increased the effect of methamphetamine. The enhancement of methamphetamine-induced stereotyped behavior was very marked when quinine was given prior to or simultaneously with methamphetamine. However, the time for onset of methamphetamine-induced stereoty...

Abstract Background The location of Plasmodium falciparum within the body is determined by life cycle parasite; young rings are in peripheral blood, whereas mature parasites sequestered deep tissues. We can calculate a “ring ratio”, proportion periphery to total number body. Artesunate acts on all parasite stages, quinine effective only parasites. Children with cerebral malaria (CM) treated art...

Morphine pretreatment attenuates aversive taste reactions elicited by quinine solution when assessed by the taste reactivity test. To determine whether this effect changes across trials, rats were administered morphine (2 mg/kg, subcutaneously) 30 min before a 5-min intraoral infusion of quinine solution (0.05%) on each of eight trials. Neither tolerance nor sensitization developed to morphine-...

BACKGROUND Skeletal muscle cramps affect over a third of the ambulatory elderly population. Quinine is the established treatment, but there are safety concerns, and evidence for efficacy is conflicting. A recent meta-analysis established a small advantage for quinine, but identified the need for additional studies. N-of-1 trials compare two treatments, in a randomised, double-blind, multiple cr...

Although quinine, the active ingredient of chinchona bark, has been used in the treatment of malaria for several centuries, there is little information regarding the interactions of this drug with the human malaria parasite Plasmodium falciparum. To better understand quinine's mode of action and the mechanism underpinning reduced responsiveness, we have investigated the factors that contribute ...