Introduction: The proton beam produced in particle accelerators has an appropriate therapeutic potential. In this research, proton therapy of breast cancer is simulated using the MCNPX code in a MIRD phantom, also the contribution of scattered neutron dose during the proton therapy were calculated for the Heart, Lung and Liver.   Materials and Methods: For si...

Radiation therapy for the treatment of thoracic malignancies has improved significantly by directing of the proton beam in higher doses on the targeted tumor while normal tissues around the tumor receive much lower doses. Nevertheless, exposure of normal tissues to protons is known to pose a substantial risk in long-term survivors, as confirmed by our work in space-relevant exposures of murine ...

Dermatofibrosarcoma protuberans (DFSP) is a rare and low-grade sarcoma of fibroblast origin with tendency to invade recur locally. The most common sites DFSP are the head, neck, extremities. However, breast has also been reported. It infiltrates surrounding subcutaneous tissue fascia, an incidence <2% for lung metastases. Surgery being main modality treatment, literature shown that radiation...

Introduction: Introduction: Radiation causes damage to irradiated tissues and also tissues that do not receive direct irradiation through a phenomenon called bystander effects. Melatonin as a potent antioxidant and anti-inflammatory agent is known for protection of normal tissues against ionizing irradiation. In addition, some studies have suggested that Melatonin may have some...

Introduction: An accurate and fast radiation dose calculation is essential for successful radiation radiotherapy. The aim of this study was to implement a new graphic processing unit (GPU) based radiation therapy treatment planning for accurate and fast dose calculation in radiotherapy centers. Materials and Methods: A program was written for parallel runnin...

Stereotactic body radiation therapy (SBRT) has evolved over the past 15 years and revolutionized the management of early stage non-small cell lung cancer (NSCLC). Compared to conventional radiation therapy, SBRT offers superior outcomes, lower costs and greater patient convenience.1 SBRT likewise offers local control and cancer outcomes approaching surgical resection2-8 with lower risk of treat...

background: to investigate the expression of tnf-α, il-6, il-10 in the plasma of patients with lung cancer who received radiation therapy (rt), and to analyze the correlation between these cytokines and radiation pneumonitis (rp). materials and methods: patients with lung cancer who received 3d-crt in our hospital were prospectively evaluated. circulating cytokine levels were measured with elis...

INTRODUCTION Radiation therapy for lung cancer causes pneumonitis and fibrosis. Soy isoflavones protect against radiation-induced lung injury, but the mediators of radioprotection remain unclear. We investigated the effect of radiation on myeloid-derived suppressor cells (MDSCs) in the lung and their modulation by soy isoflavones for a potential role in protection from radiation-induced lung in...

Introduction: Proton therapy delivers radiation to tumor tissue in a much more confined way than conventional photon therapy thus allowing the radiation oncologist to use a greater dose while still minimizing side.   Materials and Methods: protons release most of their energy within the tumor region. As a result, the treating physician can potentially give an...