Introduction In this article, we report the results of our investigation on comparison of radiobiological aspects of treatment plans with linear accelerator-based intensity-modulated radiation therapy and volumetric-modulated arc therapy for patients having hippocampal avoidance whole-brain radiation therapy. Materials and Methods In this retrospective study using the dose-volume histogram, w...

Published survival data for Chinese hamster ovarian cells CHO-K1 and their radiosensitive mutant xrs5 after irradiation by carbon ions of energies from 2.4 to 266.4 MeV u(-1) have been analysed using the probabilistic two-stage radiobiological model, which enables to represent the interplay of damage induction and repair processes. The results give support for the hypothesis that the difference...

In this review, we discuss the use of a variety of 3-D models (particularly 3-D skin, lung, breast and endothelial) in radiobiological research and highlight the differences in responses compared to 2-D culturing conditions (monolayers). We review the characteristics of existing 3-D models and aim to point out the substantial advantages 3-D cultures provide for modern radiobiology. In particula...

in this review, we discuss the use of a variety of 3-d models (particularly 3-d skin, lung, breast and endothelial) in radiobiological research and highlight the differences in responses compared to 2-d culturing conditions (monolayers). we review the characteristics of existing 3-d models and aim to point out the substantial advantages 3-d cultures provide for modern radiobiology. in particula...

Radiobiological models are essential components of modern radiotherapy. They are increasingly applied to optimize and evaluate the quality of different treatment planning modalities. They are frequently used in designing new radiotherapy clinical trials by estimating the expected therapeutic ratio of new protocols. In radiobiology, the therapeutic ratio is estimated from the expected gain in tu...

The development of radiobiological models made it possible to mathematically describe biological phenomena in the body under influence radiation. history began immediately after discovery X-rays and continues now, overcoming more restrictions. practical application is an integral part clinical practice cancer treatment.

Radioembolization (RE) of liver cancer with (90)Y-microspheres has been applied in the last two decades with notable responses and acceptable toxicity. Two types of microspheres are available, glass and resin, the main difference being the activity/sphere. Generally, administered activities are established by empirical methods and differ for the two types. Treatment planning based on dosimetry ...

Here it is mathematically shown that the Linear Quadratic model insuffcient to adequately describe survival curve of some cell lines, and β parameter this dependent on dose range used for fitting. Therefore, higher-order polynomials are needed have a single formula describes all lines at ranges. Based Taylor series two mathematical hypotheses, possible show free parameters each other. A new app...

At present various sites around the world use beams of swift protons or carbon ions for radiotherapy. The success of the GSI C radiotherapy pilot project has triggered the planning and/or construction of numerous clinical ion facilities in Germany (Heidelberg, Marburg, Berlin) and Europe (CNAO, MedAustron, Etoile). These sites will use carbon ions and also protons as their prime modalities. The...