نتایج جستجو برای: ras models
تعداد نتایج: 935979 فیلتر نتایج به سال:
Ras interacts with many downstream effectors that regulate complex cytoplasmic signaling networks. In this issue, Gupta et al. (2007) use mouse models of Ras-mediated tumorigenesis to show that the interaction of Ras with a single isoform of phosphatidylinositol 3-kinase (PI3K), called p110alpha (PIK3CA), is critical for tumor formation. This result will stimulate re-evaluation of pharmacologic...
The genetic landscape of pancreatic cancer shows nearly ubiquitous mutations of K-RAS. However, oncogenic K-Ras(mt) alone is not sufficient to lead to pancreatic ductal adenocarcinoma (PDAC) in either human or in genetically modified adult mouse models. Many stimulants, such as high fat diet, CCK, LPS, PGE2 and others, have physiological effects at low concentrations that are mediated in part t...
Activation of the N-ras gene by point mutations occurs in about 15 % of all human melanomas. Using recently established melanoma severe combined immunodeficiency-human mouse xenotransplantation models, here we further investigate the biological significance of these mutations. We demonstrate that activated N-ras significantly contributes to the chemoresistance of human melanoma both in vitro an...
The modern intensive care unit (ICU) has become a complex, expensive, data-intensive environment. Caregivers maintain an overall assessment of their patients based on important observations and trends. If an advanced monitoring system could also reliably provide a systemic interpretation of a patient’s observations it could help caregivers interpret these data more rapidly and perhaps more accu...
Chemical multiequilibria systems can be monitored efficiently with the aid of spectroscopic techniques. Both hard- and soft-modeling are effective and powerful tools to extract chemical information from spectroscopic data. Recently, hybrid approaches that combine the flexibility of soft-modeling with the precise solutions provided by hard-modeling have been proposed. Here, we tested the perform...
Molecular dissection of effector mechanisms of RAS-mediated resistance to anti-EGFR antibody therapy
Monoclonal antibodies targeting the epidermal growth factor receptor (EGFR), cetuximab and panitumumab, are a mainstay of metastatic colorectal cancer (mCRC) treatment. However, a significant number of patients suffer from primary or acquired resistance. RAS mutations are negative predictors of clinical efficacy of anti-EGFR antibodies in patients with mCRC. Oncogenic RAS activates the MAPK and...
ABSTRACT- Measurement of irrigation water in agricultural areas is necessary, especially, in arid and semi-arid regions. Long-throated flumes have been used to measure irrigation water and are known to be inexpensive devices with high performances. In these structures, head-discharge tables are predicted theoretically with no need to calibrate. In this study, the model of LOTF ...
The K-, N-, and HRas small GTPases are key regulators of cell physiology and are frequently mutated in human cancers. Despite intensive research, previous efforts to target hyperactive Ras based on known mechanisms of Ras signaling have been met with little success. Several studies have provided compelling evidence for the existence and biological relevance of Ras dimers, establishing a new mec...
BACKGROUND AND OBJECTIVE Renin-angiotensin system (RAS) inhibitors reduce glomerular injury and proteinuria, indicating that angiotensin II (Ang II) is involved in glomerular diseases. Although the local RAS is reported to play an essential role in maintaining local tissue functions, the role of the local RAS in regulating glomerular function is not well evaluated. In this study, we analyzed th...
Much has been written in the past few decades about the reasons why many research articles (RAs) do not find their ways into well-established academic journals. While some doubt viable comparison between "big" English-language journals (to use Swales' 2004 words) or international journals (IJs) and "small" ones published in other local languages, there is still a good many reasons to hope for t...
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