The association of insulin-like growth factor-1 (IGF-1) polymorphism with growth trait was investigated in native Desi chicken of Pakistan. The present study was conducted at Animal Genetics Laboratory of Department of Livestock Production, UVAS Lahore. Fifty Desi chicken were procured from a conventional production farm situated in the vicinity of Ravi Campus for phenotypic and genotypic analy...

Leptin gene is considered as marker of production and reproduction traits in dairy or beef cattle. The aim of this study was to investigate the genetic polymorphism in LEP gene in Hariana cows and their associations with reproduction traits. The blood samples were collected from 62 Hariana cows and analyzed in order to identify LEP/BsaAI (BTA 4, intron 2 and exon 3) genotypes using PCR-RFLP met...

Knowledge of the molecular biology of hepatitis A virus (HAV) has increased exponentially since its identification. HAV exploits all known mechanisms of genetic variation to ensure survival, including mutation and genetic recombination. HAV has been characterized by the emergence of different genotypes, three human antigenic variants and only one major serotype. This paper reviews the genetic v...

BACKGROUND Only 10-15% of smokers develop chronic obstructive pulmonary disease (COPD) which indicates genetic susceptibility to the disease. Recent studies suggested an association between COPD and polymorphisms in CHRNA coding subunits of nicotinic acetylcholine receptor. Herein, we performed a meta-analysis to clarify the impact of CHRNA variants on COPD. METHODS We searched Web of Knowled...

BACKGROUND European (E) variants of HPV 16 are evenly distributed among world regions, meanwhile Non-European variants such as European-Asian (EAs), Asian American (AA) and African (Af) are mostly confined to Eastern Asia, The Americas and African regions respectively. Several studies have shown that genetic variation of HPV 16 is associated with the risk of cervical cancer, which also seems to...

Multiple sclerosis (MS) is a demyelinating neuro- inflammatory autoimmune disease of the central nervous system. Genetic predisposition has long been suspected in the etiology of this disease. The association between MTHFR polymorphisms and MS has been ivestigated in different ethnic groups. We investigated the association between MTHFR C677T and A1298C missense variants and MS in 180 patients ...

β-lactoglobulin is the major whey protein in ruminant milk. In sheep, three genetic variants have been found (A, B and C) which differ from each other by a single base substitution within exon II of the gene. Various reports have indicated that the B variant is associated with higher milk yields. In this study, we have assessed the genotypic frequencies of both A and B variants in samples from ...

Background: Osteogenesis imperfecta (OI) is a clinically and genetically heterogeneous disorder characterized by bone loss and bone fragility. The aim of this study was to investigate the variants of three genes involved in the pathogenesis of OI. Methods: Molecular genetic analyses were performed for COL1A1, COL1A2, and CRTAP genes in an Iranian family with OI. The DNA samples were analyzed by...