Macrophage/microglia with heterogonous phenotype and function under physiological and pathological conditions are the main cell lineage involved in inducing immune responses in neuroinflammatory diseases which exhibit combined inflammatory and anti-inflammatory functions. An increase in the expression of iNOS triggers M1 phenotype that secrete high concentrations of inflammatory cytokines, whil...

Let $D$ be the open disk $|x|< R$ of a complete ultrametric algebraically closed field $\mathbb K$. We define growth order $\rho(f)$, type $\sigma(f)$ cotype $\psi(f)$ and another expression $\theta(f)$ an analytic function in we show relations between number zeros $f$ ``maximum modulus'' involving $\rho,\sigma,\psi$. Then $\rho(f)$ lies $[\theta(f)-1, \theta(f)]$. Moreover, if $0< \rho(f)< +\i...

Five mutant rho proteins, representing alterations at three different locations in the Escherichia coli rho gene that affect ATP hydrolytic activity but not RNA binding, were examined in vivo for function at the rho-dependent IS2 and bacteriophage lambda tR1 terminators. The altered amino acids in rho are located at highly conserved residues near the beta 1 and beta 4 strands of the hydrophobic...

The generalized odds-rate class of regression models for time to event data is indexed by a non-negative constant rho and assumes that [formula: see text] where g: rho(s) = log(rho-1(s-rho - 1)) for rho > 0, g0(s) = log(-logs), S(t[symbol: see text]Z) is the survival function of the time to event for an individual with q x 1 covariate vector Z, beta is a q x 1 vector of unknown regression param...

The bacterial transcription terminator, Rho, terminates transcription at half of the operons. According to the classical model derived from in vitro assays on a few terminators, Rho is recruited to the transcription elongation complex (EC) by recognizing specific sites (rut) on the nascent RNA. Here, we explored the mode of in vivo recruitment process of Rho. We show that sequence specific reco...

BACKGROUND Statins improve endothelial function by upregulating endothelial nitric oxide (NO) production that is mediated by inhibiting the isoprenylation of rho GTPase. Withdrawal of statin treatment could suppress endothelial NO production and may impair vascular function. METHODS AND RESULTS To test this hypothesis, mice were treated for 14 days with 10 mg/kg atorvastatin per day; this led...

The present study was carried out to investigate independent relationship between daily physical activity, microalbuminuria, and kidney function. The demographic characteristics and laboratory parameters were recorded for all patients. The determination of daily activities was carried out by Nottingham Extended Activities of Daily Living Scale (NEADLS) which was performed for each patient in an...

Background: Endometriosis, a disease affecting 3-10% of women of reproductive age, is characterized by the ectopic growth of endometrial glands and stroma surrounded by dense fibrous tissue. Whereas, normal eutopic endometrium shows scarless tissue repair during menstrual cycles, which suggests that the endometriotic tissues have distinct mechanisms of fibrogenesis. During the development of en...