نتایج جستجو برای: ribosomal peptide synthetases
تعداد نتایج: 193415 فیلتر نتایج به سال:
Halogenation plays a significant role in the activity of the glycopeptide antibiotics (GPAs), although up until now the timing and therefore exact substrate involved was unclear. Here, we present results combined from in vivo and in vitro studies that reveal the substrates for the halogenase enzymes from GPA biosynthesis as amino acid residues bound to peptidyl carrier protein (PCP)-domains fro...
Class III lanthipeptide synthetases catalyze the formation of lanthionine/methyllanthionine and labionin crosslinks. We present here 2.40 Å resolution structure kinase domain a class synthetase CurKC from biosynthesis curvopeptin. A unique structural subunit for leader binding, named recognition (LRD), was identified. The LRD is responsible peptide mediating interactions between lyase domains. ...
In this study, the function of a non-ribosomal peptide synthetase-like (NRPS-like) encoding gene AOL_s00188g306 ( g306 ) was investigated to reveal association between NRPS and nematocidal activity in nematode-trapping fungus Arthrobotrys oligospora . Sequence analysis indicated that encoded product is an adenylation domain synthetases extended short-chain dehydrogenase/reductase domain-contain...
Biomimetic N-acetylcysteamine thioesters are essential for the study of polyketide synthases, non-ribosomal peptide synthetases and fatty acid synthases. The chemistry their preparation is, however, limited by specific functionalization susceptibility to undesired side reactions. Here we report a method rapid (SNAC) 7-hydroxy-2-enethioates, which suitable various enzymatic domains megasynthase ...
Three non-ribosomal peptide synthetase genes, termed sidD, sidC and sidE, have been identified in Aspergillus fumigatus. Gene expression analysis by RT-PCR confirms that expression of both sidD and C was reduced by up to 90% under iron-replete conditions indicative of a likely role in siderophore biosynthesis. SidE expression was less sensitive to iron levels. In addition, two proteins purified...
SUMMARY Non-ribosomal peptide synthetases (NRPSs) are multi-modular enzymes, which biosynthesize many important peptide compounds produced by bacteria and fungi. Some studies have revealed that an individual domain within the NRPSs shows significant substrate selectivity. The discovery and characterization of non-ribosomal peptides are of great interest for the biotechnological industries. We h...
Paenibacillus polymyxa is a common soil bacterium with broad range of practical applications. An important group of secondary metabolites in P. polymyxa are non-ribosomal peptide and polyketide derived metabolites (NRPs/PKs). Modular non-ribosomal peptide synthetases catalyze main steps in the biosynthesis of the complex secondary metabolites. Here we report on the inactivation of an A26 Sfp-ty...
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